Literature DB >> 2793968

High-performance liquid chromatographic determination of ibuprofen, its metabolites and enantiomers in biological fluids.

G Geisslinger1, K Dietzel, D Loew, O Schuster, G Rau, G Lachmann, K Brune.   

Abstract

An isocratic high-performance liquid chromatographic method to determine racemic ibuprofen (assay I) and its major metabolites (assay II) in biological fluids (plasma, urine, bile) using a conventional reversed-phase column is described. A third assay using beta-cyclodextrin as stationary phase (Cyclobond I) for the separation of the ibuprofen enantiomers is also described. A wavelength of 220 nm was used to monitor the substances. The sensitivity of the method was 0.1 microgram/ml for all three assays. The method was demonstrated to be suitable for stereoselective pharmacokinetic studies of ibuprofen in humans and animals.

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Year:  1989        PMID： 2793968     DOI： 10.1016/s0378-4347(00)82827-3

Source DB:  PubMed          Journal:  J Chromatogr


  12 in total

1.  Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved.

Authors:  W S Beck; H T Schneider; K Dietzel; B Nuernberg; K Brune
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

Review 2.  Clinical pharmacokinetics of ibuprofen. The first 30 years.

Authors:  N M Davies
Journal:  Clin Pharmacokinet       Date:  1998-02       Impact factor: 6.447

3.  Interaction of ibuprofen and probenecid with drug metabolizing enzyme phenotyping procedures using caffeine as the probe drug.

Authors:  Fatima Vrtic; Walter E Haefeli; Jürgen Drewe; Stephan Krähenbühl; Markus Wenk
Journal:  Br J Clin Pharmacol       Date:  2003-02       Impact factor: 4.335

4.  Pharmacological differences between R(-)- and S(+)-ibuprofen.

Authors:  G Geisslinger; K P Stock; G L Bach; D Loew; K Brune
Journal:  Agents Actions       Date:  1989-06

5.  Glucuronidation and covalent protein binding of benoxaprofen and flunoxaprofen in sandwich-cultured rat and human hepatocytes.

Authors:  Jennifer Q Dong; Philip C Smith
Journal:  Drug Metab Dispos       Date:  2009-09-22       Impact factor: 3.922

6.  Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.

Authors:  G Geisslinger; K P Stock; D Loew; G L Bach; K Brune
Journal:  Br J Clin Pharmacol       Date:  1993-06       Impact factor: 4.335

7.  Biliary elimination of non-steroidal anti-inflammatory drugs in patients.

Authors:  H T Schneider; B Nuernberg; K Dietzel; K Brune
Journal:  Br J Clin Pharmacol       Date:  1990-01       Impact factor: 4.335

8.  The relation between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery.

Authors:  G Van den Mooter; C Samyn; R Kinget
Journal:  Pharm Res       Date:  1994-12       Impact factor: 4.200

9.  Dose-related effects of ibuprofen on pain-related potentials.

Authors:  G Kobal; C Hummel; M Gruber; G Geisslinger; T Hummel
Journal:  Br J Clin Pharmacol       Date:  1994-05       Impact factor: 4.335

10.  The biliary elimination and enterohepatic circulation of ibuprofen in rats.

Authors:  K Dietzel; W S Beck; H T Schneider; G Geisslinger; K Brune
Journal:  Pharm Res       Date:  1990-01       Impact factor: 4.200
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