Ayse Kirbas1, Korkut Daglar2, Gulenay Gencosmanoglu2, Zehra Yilmaz2, Hakan Timur2, Zeynep Inal3, Aykan Yucel2, Nuri Danisman2. 1. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Electronic address: drayse1982@yahoo.com. 2. Department of Perinatology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. 3. Department of Obstetrics and Gynecology, Konya Education and Research Hospital, Konya, Turkey.
Abstract
AIM: This study was carried out due to the discussions in the literature stating that the inverse association between placenta previa (PP) and preeclampsia (PE). The aim of this study was to determine whether total antioxidant status (TAS), and total oxidant status (TOS) and ADAMTS-12 levels differ among early-onset (<34th gestational week) severe PE (EOS-PE), PP and uncomplicated pregnancies. METHODS: In this case-control study, serum samples obtained from 26 pregnant with EOS-PE, 31 pregnant with PP, and 32 healthy patients with uncomplicated pregnancies (control group). RESULTS: TOS levels were significantly higher in the EOS-PE than in the control group and PP groups (p=0.002, p=0.05, respectively). TAS levels were significantly lower in the EOS-PE than in the control (p<0.001). Although TAS levels were lower in the EOS-PE group than in the PP group, the differences were not statistically significant (p=0.09). There were no significant differences in the ADAMTS-12 levels of the groups. DISCUSSION: The data in this study suggested that the balance between oxidative and anti-oxidative substances were comparable and normal in pregnancies complicated by PP when compared to normal pregnancies without placentation abnormality. In support of this, we encountered no case with PE and fetal growth restriction in our study groups suggesting normal placental angiogenesis. Contrarily, EOS-PE was associated with decreased TAS and increased TOS levels in the maternal serum.
AIM: This study was carried out due to the discussions in the literature stating that the inverse association between placenta previa (PP) and preeclampsia (PE). The aim of this study was to determine whether total antioxidant status (TAS), and total oxidant status (TOS) and ADAMTS-12 levels differ among early-onset (<34th gestational week) severe PE (EOS-PE), PP and uncomplicated pregnancies. METHODS: In this case-control study, serum samples obtained from 26 pregnant with EOS-PE, 31 pregnant with PP, and 32 healthy patients with uncomplicated pregnancies (control group). RESULTS:TOS levels were significantly higher in the EOS-PE than in the control group and PP groups (p=0.002, p=0.05, respectively). TAS levels were significantly lower in the EOS-PE than in the control (p<0.001). Although TAS levels were lower in the EOS-PE group than in the PP group, the differences were not statistically significant (p=0.09). There were no significant differences in the ADAMTS-12 levels of the groups. DISCUSSION: The data in this study suggested that the balance between oxidative and anti-oxidative substances were comparable and normal in pregnancies complicated by PP when compared to normal pregnancies without placentation abnormality. In support of this, we encountered no case with PE and fetal growth restriction in our study groups suggesting normal placental angiogenesis. Contrarily, EOS-PE was associated with decreased TAS and increased TOS levels in the maternal serum.
Authors: Carmen A H Severens-Rijvers; Salwan Al-Nasiry; Annemiek Vincken; Guido Haenen; Bjorn Winkens; Chahinda Ghossein-Doha; Marc A E Spaanderman; Louis L H Peeters Journal: Gynecol Obstet Invest Date: 2019-07-29 Impact factor: 2.031
Authors: John Henry Dasinger; Justine M Abais-Battad; David L Mattson Journal: Am J Physiol Regul Integr Comp Physiol Date: 2020-05-20 Impact factor: 3.619
Authors: Polina A Vishnyakova; Maria A Volodina; Nadezhda V Tarasova; Maria V Marey; Natalya E Kan; Zulfiya S Khodzhaeva; Mikhail Yu Vysokikh; Gennady T Sukhikh Journal: BBA Clin Date: 2017-07-03