| Literature DB >> 27939463 |
Rahana Rahman1, Padma Murthi2, Harmeet Singh3, Seshini Gurusinghe4, Joanne C Mockler4, Rebecca Lim3, Euan M Wallace5.
Abstract
Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.Entities:
Keywords: Endothelial dysfunction; Endothelin-1; Hydroxychloroquine; Preeclampsia; Preeclamptic serum; TNF-α
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Year: 2016 PMID： 27939463 DOI： 10.1016/j.preghy.2016.09.001
Source DB: PubMed Journal: Pregnancy Hypertens ISSN： 2210-7789 Impact factor: 2.899