Literature DB >> 27939452

MHC Bias by T Cell Receptors: Genetic Evidence for MHC and TCR Coevolution.

Brian M Baker1, Brian D Evavold2.   

Abstract

Major histocompatibility complex (MHC) restriction is a fundamental tenet of T cell biology, but the underlying mechanisms have remained controversial. The extent to which T cell receptors (TCRs) are biased towards MHC proteins in particular has been widely discussed. In a recent paper, Sharon et al. report direct evidence for coevolution between TCR and MHC genes, helping to explain how MHC compatibility and bias can be encoded within TCRs.
Copyright © 2016 Elsevier Ltd. All rights reserved.

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Year:  2016        PMID： 27939452      PMCID： PMC5208042          DOI： 10.1016/j.it.2016.11.003

Source DB:  PubMed          Journal:  Trends Immunol        ISSN： 1471-4906            Impact factor:   16.687


  15 in total

1.  Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1.

Authors:  J Hennecke; A Carfi; D C Wiley
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

2.  How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire.

Authors:  Sydney J Blevins; Brian G Pierce; Nishant K Singh; Timothy P Riley; Yuan Wang; Timothy T Spear; Michael I Nishimura; Zhiping Weng; Brian M Baker
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-16       Impact factor: 11.205

3.  Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response.

Authors:  Stephanie Gras; Jesseka Chadderton; Claudia M Del Campo; Carine Farenc; Florian Wiede; Tracy M Josephs; Xavier Y X Sng; Michiko Mirams; Katherine A Watson; Tony Tiganis; Kylie M Quinn; Jamie Rossjohn; Nicole L La Gruta
Journal:  Immunity       Date:  2016-10-04       Impact factor: 31.745

Review 4.  T cell receptor bias for MHC: co-evolution or co-receptors?

Authors:  Sneha Rangarajan; Roy A Mariuzza
Journal:  Cell Mol Life Sci       Date:  2014-03-17       Impact factor: 9.261

5.  T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.

Authors:  Dennis X Beringer; Fleur S Kleijwegt; Florian Wiede; Arno R van der Slik; Khai Lee Loh; Jan Petersen; Nadine L Dudek; Gaby Duinkerken; Sandra Laban; Antoinette Joosten; Julian P Vivian; Zhenjun Chen; Adam P Uldrich; Dale I Godfrey; James McCluskey; David A Price; Kristen J Radford; Anthony W Purcell; Tatjana Nikolic; Hugh H Reid; Tony Tiganis; Bart O Roep; Jamie Rossjohn
Journal:  Nat Immunol       Date:  2015-10-05       Impact factor: 25.606

6.  αβ T cell receptors that do not undergo major histocompatibility complex-specific thymic selection possess antibody-like recognition specificities.

Authors:  Anastasia N Tikhonova; François Van Laethem; Ken-ichi Hanada; Jinghua Lu; Leonid A Pobezinsky; Changwan Hong; Terry I Guinter; Susanna K Jeurling; Günter Bernhardt; Jung-Hyun Park; James C Yang; Peter D Sun; Alfred Singer
Journal:  Immunity       Date:  2011-12-29       Impact factor: 31.745

7.  A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands.

Authors:  Brian D Stadinski; Peter Trenh; Rebecca L Smith; Bianca Bautista; Priya G Huseby; Guoqi Li; Lawrence J Stern; Eric S Huseby
Journal:  Immunity       Date:  2011-11-23       Impact factor: 31.745

8.  TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms.

Authors:  Oleg Y Borbulevych; Sujatha M Santhanagopolan; Moushumi Hossain; Brian M Baker
Journal:  J Immunol       Date:  2011-07-27       Impact factor: 5.422

Review 9.  The molecular basis of TCR germline bias for MHC is surprisingly simple.

Authors:  K Christopher Garcia; Jarrett J Adams; Dan Feng; Lauren K Ely
Journal:  Nat Immunol       Date:  2009-02       Impact factor: 25.606

10.  Genetic variation in MHC proteins is associated with T cell receptor expression biases.

Authors:  Eilon Sharon; Leah V Sibener; Alexis Battle; Hunter B Fraser; K Christopher Garcia; Jonathan K Pritchard
Journal:  Nat Genet       Date:  2016-08-01       Impact factor: 38.330
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  2 in total

1.  NMR-directed design of pre-TCRβ and pMHC molecules implies a distinct geometry for pre-TCR relative to αβTCR recognition of pMHC.

Authors:  Robert J Mallis; Haribabu Arthanari; Matthew J Lang; Ellis L Reinherz; Gerhard Wagner
Journal:  J Biol Chem       Date:  2017-11-03       Impact factor: 5.157

Review 2.  GVHD Pathogenesis, Prevention and Treatment: Lessons From Humanized Mouse Transplant Models.

Authors:  Nicholas J Hess; Matthew E Brown; Christian M Capitini
Journal:  Front Immunol       Date:  2021-07-29       Impact factor: 7.561
  2 in total

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