| Literature DB >> 27939444 |
J Thomas Mock1, Kiran Chaudhari1, Akram Sidhu1, Nathalie Sumien2.
Abstract
Age-related declines in motor and cognitive function have been associated with increases in oxidative stress. Accordingly, interventions capable of reducing the oxidative burden would be capable of preventing or reducing functional declines occurring during aging. Popular interventions such as antioxidant intake and moderate exercise are often recommended to attain healthy aging and have the capacity to alter redox burden. This review is intended to summarize the outcomes of antioxidant supplementation (more specifically of vitamins C and E) and exercise training on motor and cognitive declines during aging, and on measures of oxidative stress. Additionally, we will address whether co-implementation of these two types of interventions can potentially further their individual benefits. Together, these studies highlight the importance of using translationally-relevant parameters for interventions and to study their combined outcomes on healthy brain aging.Entities:
Keywords: Aging; Antioxidants; Brain function; Cognition; Exercise; Motor function; Vitamin C; Vitamin E
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Year: 2016 PMID： 27939444 PMCID： PMC5466517 DOI： 10.1016/j.exger.2016.12.008
Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032