| Literature DB >> 27939348 |
Yen-Ta Lu1, Tien-Ling Chen2, Kuo-Song Chang3, Chia-Ming Chang4, Tsai-Yin Wei4, Jen-Wei Liu5, Chih-Ang Hsiao5, Tzenge-Lien Shih6.
Abstract
Novel C4-benzazole naphthalimide derivatives were synthesized and tested in vitro and in vivo as anti-cancer drugs. Among these synthetic molecules, compounds 9 and 10 exhibited cytotoxicity against murine B16F10 melanoma cells. In addition, the above-mentioned compounds significantly suppressed lung tumor metastasis with no visible sign of toxicity.Entities:
Keywords: B16F10 cells; Benzazole; MTS assay; Melanoma; Naphthalimide; Topoisomerase II
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Year: 2016 PMID： 27939348 DOI： 10.1016/j.bmc.2016.11.057
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641