Literature DB >> 27936462

Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia.

María Angélica Contreras-Gutiérrez1, Marcio R T Nunes2, Hilda Guzman3, Sandra Uribe4, Juan David Suaza Vasco1, Jedson F Cardoso2, Vsevolod L Popov3, Steven G Widen5, Thomas G Wood5, Nikos Vasilakis6, Robert B Tesh7.   

Abstract

The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Insect-specific viruses; Orthomyxoviridae; Sinu virus; Thogotovirus genus

Mesh：

Substances：

Year:  2016        PMID： 27936462      PMCID： PMC5201441          DOI： 10.1016/j.virol.2016.11.014

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


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