Kenneth Lai1,2,3,4, Murray Killingsworth2,3,4,5, Slade Matthews6,7, Nicole Caixeiro2,3, Carlyn Evangelista4, Xiao Wu4, James Wykes5,8, Alan Samakeh8, Dion Forstner5,9, Navin Niles8, Angela Hong10, Cheok Soon Lee1,2,3,4,5. 1. Cancer Pathology, Bosch Institute, The University of Sydney, Sydney, Australia. 2. Discipline of Pathology, School of Medicine, Western Sydney University, Sydney, Australia. 3. Centre for Oncology Education and Research Translation (CONCERT), Ingham Institute for Applied Medical Research, Sydney, Australia. 4. Department of Anatomical Pathology, Sydney South West Pathology Service (SSWPS) Liverpool Hospital, Sydney, Australia. 5. Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia. 6. Sydney Medical School (Pharmacology), The University of Sydney, Sydney, Australia. 7. Bosch Institute, The University of Sydney, Sydney, Australia. 8. Department of Head & Neck Surgery, Liverpool Hospital, Sydney, Australia. 9. Department of Radiation Oncology, Liverpool Hospital, Sydney, Australia. 10. Central Clinical School, University of Sydney, Sydney, Australia.
Abstract
BACKGROUND: This study examined the prognostic significance of human papillomavirus (HPV) in patients with oropharyngeal and oral cavity squamous cell carcinoma (SCC). METHODS: Tissue microarrays were constructed from oropharyngeal and oral cavity SCC (n = 143). The presence of functional HPV in tumour was determined by combined assessments of p16 immunohistochemistry and HPV in situ hybridisation. RESULTS: Oropharyngeal SCC patients presented with more advanced disease in comparison with oral cavity SCC patients (P = 0.001). HPV is present in 60% and 61% of oropharyngeal and oral cavity SCC patients, respectively. HPV-positive oropharyngeal SCC patients with advanced TNM stages displayed better overall and disease-free survival outcomes than HPV-negative patients (P = 0.022 and 0.046, respectively). Such survival differences were not observed in oral cavity SCC. CONCLUSIONS: HPV is common in both oropharyngeal and oral cavity SCC and is associated with better survival outcome in oropharyngeal SCC but not in oral cavity SCC patients.
BACKGROUND: This study examined the prognostic significance of human papillomavirus (HPV) in patients with oropharyngeal and oral cavity squamous cell carcinoma (SCC). METHODS: Tissue microarrays were constructed from oropharyngeal and oral cavity SCC (n = 143). The presence of functional HPV in tumour was determined by combined assessments of p16 immunohistochemistry and HPV in situ hybridisation. RESULTS: Oropharyngeal SCCpatients presented with more advanced disease in comparison with oral cavity SCCpatients (P = 0.001). HPV is present in 60% and 61% of oropharyngeal and oral cavity SCCpatients, respectively. HPV-positive oropharyngeal SCCpatients with advanced TNM stages displayed better overall and disease-free survival outcomes than HPV-negative patients (P = 0.022 and 0.046, respectively). Such survival differences were not observed in oral cavity SCC. CONCLUSIONS:HPV is common in both oropharyngeal and oral cavity SCC and is associated with better survival outcome in oropharyngeal SCC but not in oral cavity SCCpatients.
Authors: Alex K Bryant; Elena J Sojourner; Lucas K Vitzthum; Kaveh Zakeri; Hanjie Shen; Cammie Nguyen; James D Murphy; Joseph A Califano; Ezra E W Cohen; Loren K Mell Journal: J Natl Cancer Inst Date: 2018-12-01 Impact factor: 13.506
Authors: Kenneth Lai; Slade Matthews; James S Wilmott; Murray C Killingsworth; Jim L Yong; Nicole J Caixeiro; James Wykes; Allan Samakeh; Dion Forstner; Mark Lee; John McGuinness; Navin Niles; Angela Hong; Ardalan Ebrahimi; Cheok Soon Lee Journal: BMC Cancer Date: 2018-06-01 Impact factor: 4.430