| Literature DB >> 27934507 |
Dong Song Tian1,2, Ping Yi1, Lei Xia1, Xin Xiao2, Yi Min Fan1, Wei Gu1, Lie Jun Huang1, Yaacov Ben-David1, Ying Tong Di3, Chun Mao Yuan1, Xiao Jiang Hao1,3.
Abstract
Garmultins A and B (1 and 2), two polycyclic polyprenylated acylphloroglucinols characterized by the coupling of two novel cages, 2,11-dioxatricyclo[4.4.1.03,9]undecane and tricyclo[4.3.1.03,7]decane, along with five biogenetically related analogues (3-7), were isolated from Garcinia multiflora. Their structures and absolute configurations were determined by extensive NMR analysis, X-ray crystallography, and electronic circular dichroism calculations. Three compounds were capable of inhibiting oncogene expression and inducing apoptosis in human erythroleukemia cells.Entities:
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Year: 2016 PMID： 27934507 DOI： 10.1021/acs.orglett.6b03004
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005