Literature DB >> 27934498

Naphthoquinone-Oxindole Alkaloids, Coprisidins A and B, from a Gut-Associated Bacterium in the Dung Beetle, Copris tripartitus.

Soohyun Um, Duc-Hiep Bach, Bora Shin, Chan-Hong Ahn, Seong-Hwan Kim, Hea-Son Bang1, Ki-Bong Oh, Sang Kook Lee, Jongheon Shin, Dong-Chan Oh.   

Abstract

Coprisidins A and B (1 and 2) were isolated from a gut-associated Streptomyces sp. in the dung beetle Copris tripartitus. Using a combination of spectroscopic techniques, the structures of the compounds were determined to be the first examples of natural naphthoquinone-oxindole alkaloids. Coprisidin A was found to inhibit the action of Na+/K+-ATPase, and coprisidin B showed activity for the induction of NAD(P)H:quinone oxidoreductase 1.

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Year:  2016        PMID： 27934498     DOI： 10.1021/acs.orglett.6b02555

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  8 in total

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