| Literature DB >> 27934497 |
Pan Xiao1,2, Jian Rong1, Chuanfa Ni1, Junkai Guo1, Xinjin Li1, Dingben Chen1, Jinbo Hu1,2.
Abstract
An atom-economical method for radical (phenylsulfonyl)difluoromethylation of isocyanides with PhSO2CF2H under transition-metal-free conditions has been developed. A PhSO2CF2 radical is generated through the oxidation of PhSO2CF2- after the deprotonation of PhSO2CF2H in one pot. The reaction exhibits excellent functional-group tolerance and the resulting products can be further modified with the removal of a PhSO2 group to give other CF2-containing compounds.Entities:
Year: 2016 PMID： 27934497 DOI： 10.1021/acs.orglett.6b03013
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005