| Literature DB >> 27934390 |
Casper L Hansen1, Ragnhild G Ohm1, Lasse B Olsen1, Erhad Ascic1, David Tanner1, Thomas E Nielsen1,2.
Abstract
A synthetic strategy for the synthesis of chiral tetrahydrocarbazoles (THCAs) has been developed. The strategy relies on two types of 6-exo-trig cyclization of 3-substituted indole substrates. Enantioselective domino Friedel-Crafts-type reactions leading to THCAs can be catalyzed by chiral phosphoric acid derivatives (with up to >99% ee), and the first examples of exocyclic Pictet-Spengler reactions to form THCAs are reported.Entities:
Year: 2016 PMID： 27934390 DOI： 10.1021/acs.orglett.6b02718
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005