| Literature DB >> 27934032 |
Hailong Li1, Qifeng Chen1, Zhaohong Lu1, Ang Li1.
Abstract
The first total syntheses of aflavazole (6) and 14-hydroxyaflavinine (8), two sterically congested indole diterpenoids, were accomplished. AlI3-promoted alkyne Prins cyclization was exploited to construct their key structural motifs. An electrocyclization-aromatization sequence assembled the pentasubstituted arene of 6, and a Stille-Migita coupling furnished the tetrasubstituted olefin of 8. The benzylic and allylic C-O bonds were reductively cleaved at the late stage of the syntheses, respectively.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27934032 DOI： 10.1021/jacs.6b10880
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419