Literature DB >> 27933897

Tyrosyl-DNA Phosphodiesterase 1 Inhibitors: Usnic Acid Enamines Enhance the Cytotoxic Effect of Camptothecin.

Alexandra Zakharenko1, Olga Luzina2, Olga Koval1,3, Dmitry Nilov, Irina Gushchina, Nadezhda Dyrkheeva1, Vytas Švedas, Nariman Salakhutdinov2,3, Olga Lavrik1,3.   

Abstract

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is a repair enzyme for stalled DNA-topoisomerase 1 (Top1) cleavage complexes and other 3'-end DNA lesions. TDP1 is a perspective target for anticancer therapy based on Top1-poison-mediated DNA damage. Several novel usnic acid derivatives with an enamine moiety have been synthesized and tested as inhibitors of TDP1. The enamines of usnic acid showed IC50 values in the range of 0.16 to 2.0 μM. These compounds revealed moderate cytotoxicity against human tumor MCF-7 cells. These new compounds enhanced the cytotoxicity of the established Top1 poison camptothecin by an order of magnitude.

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Year:  2016        PMID： 27933897     DOI： 10.1021/acs.jnatprod.6b00979

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  18 in total

1.  Mechanism-informed Repurposing of Minocycline Overcomes Resistance to Topoisomerase Inhibition for Peritoneal Carcinomatosis.

Authors:  Huang-Chiao Huang; Joyce Liu; Yan Baglo; Imran Rizvi; Sriram Anbil; Michael Pigula; Tayyaba Hasan
Journal:  Mol Cancer Ther       Date:  2017-11-22       Impact factor: 6.261

2.  The influence of an enamine usnic acid derivative (a tyrosyl-DNA phosphodiesterase 1 inhibitor) on the therapeutic effect of topotecan against transplanted tumors in vivo.

Authors:  V P Nikolin; N A Popova; V I Kaledin; O A Luzina; A L Zakharenko; N F Salakhutdinov; O I Lavrik
Journal:  Clin Exp Metastasis       Date:  2021-08-09       Impact factor: 5.150

3.  Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.

Authors:  Xiao-Ru Zhang; Hao-Wen Wang; Wen-Lin Tang; Yu Zhang; Hui Yang; De-Xuan Hu; Azhar Ravji; Christophe Marchand; Evgeny Kiselev; Kwabena Ofori-Atta; Keli Agama; Yves Pommier; Lin-Kun An
Journal:  J Med Chem       Date:  2018-10-31       Impact factor: 7.446

4.  Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.

Authors:  Oksana V Salomatina; Irina I Popadyuk; Alexandra L Zakharenko; Olga D Zakharova; Dmitriy S Fadeev; Nina I Komarova; Jóhannes Reynisson; H John Arabshahi; Raina Chand; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Molecules       Date:  2018-03-17       Impact factor: 4.411

5.  A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold.

Authors:  Nikolai S Li-Zhulanov; Alexandra L Zakharenko; Arina A Chepanova; Jinal Patel; Ayesha Zafar; Konstantin P Volcho; Nariman F Salakhutdinov; Jóhannes Reynisson; Ivanhoe K H Leung; Olga I Lavrik
Journal:  Molecules       Date:  2018-09-26       Impact factor: 4.411

6.  New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.

Authors:  Aleksander S Filimonov; Arina A Chepanova; Olga A Luzina; Alexandra L Zakharenko; Olga D Zakharova; Ekaterina S Ilina; Nadezhda S Dyrkheeva; Maxim S Kuprushkin; Anton V Kolotaev; Derenik S Khachatryan; Jinal Patel; Ivanhoe K H Leung; Raina Chand; Daniel M Ayine-Tora; Johannes Reynisson; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Molecules       Date:  2019-10-15       Impact factor: 4.411

7.  Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.

Authors:  Tatyana M Khomenko; Alexandra L Zakharenko; Arina A Chepanova; Ekaterina S Ilina; Olga D Zakharova; Vasily I Kaledin; Valeriy P Nikolin; Nelly A Popova; Dina V Korchagina; Jóhannes Reynisson; Raina Chand; Daniel M Ayine-Tora; Jinal Patel; Ivanhoe K H Leung; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Int J Mol Sci       Date:  2019-12-23       Impact factor: 5.923

8.  Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties.

Authors:  Kseniya Kovaleva; Olga Yarovaya; Konstantin Ponomarev; Sergey Cheresiz; Amirhossein Azimirad; Irina Chernyshova; Alexandra Zakharenko; Vasily Konev; Tatiana Khlebnikova; Evgenii Mozhaytsev; Evgenii Suslov; Dmitry Nilov; Vytas Švedas; Andrey Pokrovsky; Olga Lavrik; Nariman Salakhutdinov
Journal:  Pharmaceuticals (Basel)       Date:  2021-05-01

Review 9.  Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.

Authors:  Ajinkya S Kawale; Lawrence F Povirk
Journal:  Nucleic Acids Res       Date:  2018-01-25       Impact factor: 16.971

10.  The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.

Authors:  Elizaveta D Gladkova; Ivan V Nechepurenko; Roman A Bredikhin; Arina A Chepanova; Alexandra L Zakharenko; Olga A Luzina; Ekaterina S Ilina; Nadezhda S Dyrkheeva; Evgeniya M Mamontova; Rashid O Anarbaev; Jóhannes Reynisson; Konstantin P Volcho; Nariman F Salakhutdinov; Olga I Lavrik
Journal:  Int J Mol Sci       Date:  2020-09-28       Impact factor: 5.923
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