P Ramirez1, L Sáenz2, P A Cascales-Campos3, M R González Sánchez1, E Llàcer-Millán1, M I Sánchez-Lorencio4, E Díaz-Rubio5, V De La Orden6, B Mediero-Valeros6, J L Navarro7, B Revilla Nuin8, A Baroja-Mazo8, J A Noguera-Velasco4, B F Sánchez1, J de la Peña9, J A Pons-Miñano10, F Sánchez-Bueno1, R Robles-Campos1, P Parrilla1. 1. Liver Transplant Unit, Department of Surgery, Clinical University Hospital Virgen de la Arrixaca-IMIB, Murcia, Spain. 2. Clinical Analysis Department, Navarre Hospital Complex, Pamplona, Spain. 3. Liver Transplant Unit, Department of Surgery, Clinical University Hospital Virgen de la Arrixaca-IMIB, Murcia, Spain. Electronic address: cascalex@yahoo.es. 4. Clinical Analysis Department, Clinical University Hospital Virgen de la Arrixaca-IMIB, Murcia, Spain. 5. Medical Oncology Department, Clinical Hospital San Carlos, Madrid, Spain. 6. CTC Unit, Medical Oncology Department, Clinical Hospital San Carlos, Madrid, Spain. 7. Department of Nuclear Medicine, Clinical University Hospital Virgen de la Arrixaca-IMIB, Murcia, Spain. 8. Biomedical Research Institute of Murcia (IMIB-Arrixaca-UMU), University Clinical Hospital "Virgen de la Arrixaca", University of Murcia, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Murcia, Spain. 9. Department of Pathology, Clinical University Hospital Virgen de la Arrixaca-IMIB, Murcia, Spain. 10. Department of Hepatology, Clinical University Hospital Virgen de la Arrixaca-IMIB, Murcia, Spain.
Abstract
INTRODUCTION: The objectives of this study are the determination of the number of circulating tumor cells (CTCs), by means of the IsoFlux enrichment system (Fluxion Biosciences Inc, San Francisco, California, United States) in patients with hepatocellular carcinoma (HCC) in compliance with the Milan criteria and on the waiting list for hepatic transplantation, as well as the study of its relation with the of α-fetoprotein levels (AFP) and positron-emission tomography-computed tomography (PET-CT) findings. PATIENTS AND METHODS: An oncologycal evaluation with PET-CT, CTCs, and AFP was conducted in 24 consecutive patients with HCC eligible for orthotopic liver transplantation according to the Milan criteria. The diagnosis of HCC was made according to clinical, biological, and radiological findings. RESULTS: We detected CTCs in peripheral blood in 21 of 24 patients (87.5%) before liver transplantation, with a mean number CTCs of 156 ± 370 (range, 2 to 1768) with statistically significant association between number of CTCs detected in peripheral blood and the time within the waiting list (P < .05), but not betwen AFP levels and standard uptake value and time to orthotopic liver transplantation (P > .05). CONCLUSIONS: PET-TC, CTCs, and AFP levels could be an essential key for the correct management of the patients with HCC on the waiting list for liver transplantation. Copyright Â
INTRODUCTION: The objectives of this study are the determination of the number of circulating tumor cells (CTCs), by means of the IsoFlux enrichment system (Fluxion Biosciences Inc, San Francisco, California, United States) in patients with hepatocellular carcinoma (HCC) in compliance with the Milan criteria and on the waiting list for hepatic transplantation, as well as the study of its relation with the of α-fetoprotein levels (AFP) and positron-emission tomography-computed tomography (PET-CT) findings. PATIENTS AND METHODS: An oncologycal evaluation with PET-CT, CTCs, and AFP was conducted in 24 consecutive patients with HCC eligible for orthotopic liver transplantation according to the Milan criteria. The diagnosis of HCC was made according to clinical, biological, and radiological findings. RESULTS: We detected CTCs in peripheral blood in 21 of 24 patients (87.5%) before liver transplantation, with a mean number CTCs of 156 ± 370 (range, 2 to 1768) with statistically significant association between number of CTCs detected in peripheral blood and the time within the waiting list (P < .05), but not betwen AFP levels and standard uptake value and time to orthotopic liver transplantation (P > .05). CONCLUSIONS: PET-TC, CTCs, and AFP levels could be an essential key for the correct management of the patients with HCC on the waiting list for liver transplantation. Copyright Â
Authors: María Lola Espejo-Cruz; Sandra González-Rubio; Javier Zamora-Olaya; Víctor Amado-Torres; Rafael Alejandre; Marina Sánchez-Frías; Rubén Ciria; Manuel De la Mata; Manuel Rodríguez-Perálvarez; Gustavo Ferrín Journal: Int J Mol Sci Date: 2021-12-03 Impact factor: 5.923
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