Literature DB >> 2793173

Not all chromosome imbalance resulting from the 11q;22q translocation is due to 3:1 segregation in first meiosis.

D H Lockwood1, A Farrier, F Hecht, J Allanson.   

Abstract

The constitutional translocation between chromosomes 11 and 22 [t(11;22)(q23.3;q11.2)] is one of the best known rearrangements in the human genome. Hitherto only one type of unbalanced karyotype, namely 47,XX or XY, +der(22) t(11;22)(q23.3;q11.2) was found among offspring of the translocation carriers. This result is the product of a 3:1 segregation at meiosis. We report an alternative unbalanced karyotype. The proband's karyotype is 47,XY,t(11;22)(q23.3;q11.2), +der(22)t(11;22)(q23.3;q11.2)pat. This finding cannot be due to nondisjunction in first meiosis of the translocation carrier.

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Year:  1989        PMID： 2793173     DOI： 10.1007/bf00285174

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  7 in total

1.  [2 cases of trisomy 11q(q231--qter) by translocation t(11;22) (q231;q111) in 2 different families].

Authors:  A Aurias; C Turc; Y Michiels; P M Sinet; D Graveleau; J Lejeune
Journal:  Ann Genet       Date:  1975-09

2.  High resolution of human chromosomes.

Authors:  J J Yunis
Journal:  Science       Date:  1976-03-26       Impact factor: 47.728

3.  The 11q;22q translocation: a collaborative study of 20 new cases and analysis of 110 families.

Authors:  L Iselius; J Lindsten; A Aurias; M Fraccaro; C Bastard; A M Bottelli; T H Bui; D Caufin; L Dalprà; N Delendi
Journal:  Hum Genet       Date:  1983       Impact factor: 4.132

4.  A deleted extra chromosome 22 identified by DNA replication banding.

Authors:  M Parslow; J J Hoo; M Garry; F Rose
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

5.  Structural aberrations of the long arm of chromosome no. 22. Report fo a family with translocation t(11;22) (q25;q11).

Authors:  W Fu; D S Borgaonkar; P P Ladewig; J Weaver; H H Pomerance
Journal:  Clin Genet       Date:  1976-12       Impact factor: 4.438

6.  Partial 11q trisomy syndrome.

Authors:  H Pihko; E Therman; I A Uchida
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

7.  Tertiary trisomy (22q11q),47,+der(22),t(11;22).

Authors:  B M Biederman; C C Lin; R B Lowry; R Somerville
Journal:  Hum Genet       Date:  1980-02       Impact factor: 4.132
  7 in total
  7 in total

1.  Clustered 11q23 and 22q11 breakpoints and 3:1 meiotic malsegregation in multiple unrelated t(11;22) families.

Authors:  T H Shaikh; M L Budarf; L Celle; E H Zackai; B S Emanuel
Journal:  Am J Hum Genet       Date:  1999-12       Impact factor: 11.025

2.  Meiotic studies of a human male carrier of the common translocation, t(11;22), suggests postzygotic selection rather than preferential 3:1 MI segregation as the cause of liveborn offspring with an unbalanced translocation.

Authors:  S J Armstrong; A S Goldman; R M Speed; M A Hultén
Journal:  Am J Hum Genet       Date:  2000-08-08       Impact factor: 11.025

3.  Involvement of 3:1 disjunction in the common reciprocal translocation t(11;22) (q23.3;q11.2)

Authors:  A C Chandley
Journal:  Hum Genet       Date:  1992 Sep-Oct       Impact factor: 4.132

4.  A unique case of der(11)t(11;22),-22 arising from 3:1 segregation of a maternal t(11;22) in a family with co-segregation of the translocation and breast cancer.

Authors:  Vaidehi Jobanputra; Wendy K Chung; April M Hacker; Beverly S Emanuel; Dorothy Warburton
Journal:  Prenat Diagn       Date:  2005-08       Impact factor: 3.050

5.  The unbalanced offspring of the male carriers of the 11q;22q translocation: nondisjunction at meiosis II in a balanced spermatocyte.

Authors:  P Simi; M Ceccarelli; A Barachini; G Floridia; O Zuffardi
Journal:  Hum Genet       Date:  1992-02       Impact factor: 4.132

6.  Unusual segregation of constitutional 11q;22q translocation may be explained by crossover in interchange segment, followed by 3:1 segregation at meiosis I.

Authors:  R H Lindenbaum
Journal:  Hum Genet       Date:  1990-06       Impact factor: 4.132

7.  Der(22)t(11;22) resulting from a paternal de novo translocation, adjacent 1 segregation, and maternal heterodisomy of chromosome 22.

Authors:  A J Dawson; A J Mears; A E Chudley; T Bech-Hansen; H McDermid
Journal:  J Med Genet       Date:  1996-11       Impact factor: 6.318
  7 in total

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