Neural communication through theta-gamma cross-frequency coupling in a bistable motion perception task.

Functional significance of the neural oscillations has been debated since long. In particular, oscillations have been suggested to play a major role in formation of communication channels between brain regions. It has been previously suggested that gamma coherence increases during communication between hemispheres when subjects perceive a horizontal motion in Stroboscopic Alternative Motion (SAM) stimulus. In addition, disruption of this coherence may change the horizontal perception of SAM. In this study, we investigated the changes of Cross-Frequency Coupling (CFC) in EEG signals from parietal and occipital cortices during horizontal and vertical perception of SAM. Our results suggested that while the strength of CFC in parietal electrodes showed no significant change, CFC in P3-P4 electrode-pair demonstrated a significant correlation during horizontal perception of SAM. Therefore, the CFC between theta- and gamma-band oscillations seems to be correlated with changes in functional interactions between brain regions. Accordingly, we propose that in addition to gamma coherence, CFC is perhaps another neurophysiological mechanism involved in neural communication.