G Borges1, C L Bagge2, C J Cherpitel3, K R Conner4, R Orozco1, I Rossow5. 1. Instituto Nacional de Psiquiatría,Mexico City,Mexico. 2. Department of Psychiatry and Human Behavior,University of Mississippi Medical Center,Jackson, MS,USA. 3. Alcohol Research Group,Emeryville, CA,USA. 4. University of Rochester Medical Center,Rochester, NY,USA. 5. National Centre for Suicide Research and Prevention,Institute of Clinical Medicine,University of Oslo,Oslo,Norway.
Abstract
BACKGROUND: No review has used a meta-analytic approach to estimate common odds ratios (ORs) for the effect of acute use of alcohol (AUA) on suicide attempts. We aim to report the results of the first meta-analysis of controlled epidemiological studies on AUA and suicide attempt. METHOD: The English-language literature on Medline, PsycINFO and Google Scholar was searched for original articles and critical review on AUA and suicide attempt (period 1996-2015). Studies had to report an OR estimate for this association. Common ORs and 95% confidence intervals (CIs) from random effects in meta-analyses for any AUA and two levels of alcohol use on suicide attempt were calculated. RESULTS: In all, seven studies provided OR estimates for the likelihood of suicide attempt by AUA, compared with those who did not drink alcohol. Studies used case-control (n 3) and case-crossover designs (n 4). Meta-analysis revealed a common OR of 6.97 (95% CI 4.77-10.17) for any AUA. Using four studies, 'low levels of acute drinking' resulted in an OR of 2.71 (95% CI 1.56-4.71) and 'high levels' had an OR of 37.18 (95% CI 17.38-79.53). CONCLUSIONS: AUA is associated with increased likelihood of a suicide attempt, particularly at high doses. Such data should be incorporated into estimates of the burden of disease associated with alcohol use, which are currently limited by a consideration of only alcohol's chronic effects. Future research should focus on the mechanisms through which AUA confers risk for attempt.
BACKGROUND: No review has used a meta-analytic approach to estimate common odds ratios (ORs) for the effect of acute use of alcohol (AUA) on suicide attempts. We aim to report the results of the first meta-analysis of controlled epidemiological studies on AUA and suicide attempt. METHOD: The English-language literature on Medline, PsycINFO and Google Scholar was searched for original articles and critical review on AUA and suicide attempt (period 1996-2015). Studies had to report an OR estimate for this association. Common ORs and 95% confidence intervals (CIs) from random effects in meta-analyses for any AUA and two levels of alcohol use on suicide attempt were calculated. RESULTS: In all, seven studies provided OR estimates for the likelihood of suicide attempt by AUA, compared with those who did not drink alcohol. Studies used case-control (n 3) and case-crossover designs (n 4). Meta-analysis revealed a common OR of 6.97 (95% CI 4.77-10.17) for any AUA. Using four studies, 'low levels of acute drinking' resulted in an OR of 2.71 (95% CI 1.56-4.71) and 'high levels' had an OR of 37.18 (95% CI 17.38-79.53). CONCLUSIONS: AUA is associated with increased likelihood of a suicide attempt, particularly at high doses. Such data should be incorporated into estimates of the burden of disease associated with alcohol use, which are currently limited by a consideration of only alcohol's chronic effects. Future research should focus on the mechanisms through which AUA confers risk for attempt.
Authors: Mark S Kaplan; Nathalie Huguet; Bentson H McFarland; Raul Caetano; Kenneth R Conner; Kurt B Nolte; Norman Giesbrecht Journal: Psychiatr Serv Date: 2016-01-04 Impact factor: 3.084
Authors: Courtney L Bagge; Han-Joo Lee; Julie A Schumacher; Kim L Gratz; Jennifer L Krull; Garland Holloman Journal: J Stud Alcohol Drugs Date: 2013-07 Impact factor: 2.582
Authors: Julie E Richards; Susan M Shortreed; Greg E Simon; Robert B Penfold; Joseph E Glass; Rebecca Ziebell; Emily C Williams Journal: Gen Hosp Psychiatry Date: 2019-12-18 Impact factor: 3.238
Authors: Laika D Aguinaldo; Aimee Goldstone; Brant P Hasler; David A Brent; Clarisa Coronado; Joanna Jacobus Journal: Psychiatry Res Date: 2021-02-23 Impact factor: 3.222