Bruno Palazzo Nazar1,2, Louise Kathrine Gregor1, Gaia Albano1,3, Angelo Marchica3, Gianluca Lo Coco3, Valentina Cardi, Janet Treasure1. 1. Department of Psychological Medicine, King's College London, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), London, UK. 2. Federal University of Rio de Janeiro, Institute of Psychiatry (IPUB-UFRJ), Brazil. 3. University of Palermo, Department of Psychology and Educational Sciences, Palermo, Italy.
Abstract
OBJECTIVE: Early response to eating disorders treatment is thought to predict a later favourable outcome. A systematic review of the literature and meta-analyses examined the robustness of this concept. METHOD: The criteria used across studies to define early response were summarised following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnostic Test Accuracy methodology was used to estimate the size of the effect. RESULTS: Findings from 24 studies were synthesized and data from 14 studies were included in the meta-analysis. In Anorexia Nervosa, the odds ratio of early response predicting remission was 4.85(95%CI: 2.94-8.01) and the summary Area Under the Curve (AUC) = .77. In Bulimia Nervosa, the odds ratio was 2.75(95%CI:1.24-6.09) and AUC = .67. For Binge Eating Disorder, the odds ratio was 5.01(95%CI: 3.38-7.42) and AUC = .71. CONCLUSION: Early behaviour change accurately predicts later symptom remission for Anorexia Nervosa and Binge Eating Disorder but there is less predictive accuracy for Bulimia Nervosa.
OBJECTIVE: Early response to eating disorders treatment is thought to predict a later favourable outcome. A systematic review of the literature and meta-analyses examined the robustness of this concept. METHOD: The criteria used across studies to define early response were summarised following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Diagnostic Test Accuracy methodology was used to estimate the size of the effect. RESULTS: Findings from 24 studies were synthesized and data from 14 studies were included in the meta-analysis. In Anorexia Nervosa, the odds ratio of early response predicting remission was 4.85(95%CI: 2.94-8.01) and the summary Area Under the Curve (AUC) = .77. In Bulimia Nervosa, the odds ratio was 2.75(95%CI:1.24-6.09) and AUC = .67. For Binge Eating Disorder, the odds ratio was 5.01(95%CI: 3.38-7.42) and AUC = .71. CONCLUSION: Early behaviour change accurately predicts later symptom remission for Anorexia Nervosa and Binge Eating Disorder but there is less predictive accuracy for Bulimia Nervosa.
Authors: Elizabeth K Hughes; Suzannah Poker; Amy Bortz; Michele Yeo; Michelle Telfer; Susan M Sawyer Journal: Front Psychiatry Date: 2020-04-21 Impact factor: 4.157
Authors: Brittany E Matheson; Sasha Gorrell; Cara Bohon; W Stewart Agras; Daniel Le Grange; James Lock Journal: Front Psychiatry Date: 2020-02-28 Impact factor: 4.157