Literature DB >> 27928723

Boosting weakened synapses to treat Alzheimer's disease.

Robert J McDonald1, Scott H Deibel2.   

Abstract

This paper highlights a recent report by Roy and colleagues showing that boosting plasticity in synapses activated during initial memory encoding ameliorates memory impairments found in the early stages of the familial version of Alzheimer's disease. Our goal was to describe the main features of the report and evaluate the approach and implications of the work.

Entities:  

Keywords:  Alzheimer’s disease; Engram; Genetics; Memory; Plasticity

Mesh:

Year:  2017        PMID: 27928723     DOI: 10.3758/s13420-016-0253-y

Source DB:  PubMed          Journal:  Learn Behav        ISSN: 1543-4494            Impact factor:   1.986


  4 in total

Review 1.  Revisiting the cholinergic hypothesis in the development of Alzheimer's disease.

Authors:  Laura A Craig; Nancy S Hong; Robert J McDonald
Journal:  Neurosci Biobehav Rev       Date:  2011-03-12       Impact factor: 8.989

2.  Optogenetic stimulation of a hippocampal engram activates fear memory recall.

Authors:  Xu Liu; Steve Ramirez; Petti T Pang; Corey B Puryear; Arvind Govindarajan; Karl Deisseroth; Susumu Tonegawa
Journal:  Nature       Date:  2012-03-22       Impact factor: 49.962

3.  Barriers to developing a valid rodent model of Alzheimer's disease: from behavioral analysis to etiological mechanisms.

Authors:  Darryl C Gidyk; Scott H Deibel; Nancy S Hong; Robert J McDonald
Journal:  Front Neurosci       Date:  2015-07-29       Impact factor: 4.677

4.  Memory retrieval by activating engram cells in mouse models of early Alzheimer's disease.

Authors:  Dheeraj S Roy; Autumn Arons; Teryn I Mitchell; Michele Pignatelli; Tomás J Ryan; Susumu Tonegawa
Journal:  Nature       Date:  2016-03-16       Impact factor: 49.962

  4 in total
  1 in total

1.  The Emergent Engram: A Historical Legacy and Contemporary Discovery.

Authors:  Bryan D Devan; Kyle Berger; Robert J McDonald
Journal:  Front Behav Neurosci       Date:  2018-08-07       Impact factor: 3.558

  1 in total

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