Jan Kühnisch1, Elisabeth Thiering2,3, Roswitha Heinrich-Weltzien4, Elmar Hellwig5, Reinhard Hickel6, Joachim Heinrich2. 1. Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians-University of Munich, Goethestraße70, 80336, Munich, Germany. jkuehn@dent.med.uni-muenchen.de. 2. Institute of Epidemiology I, Helmholtz Zentrum Munich, German Research Centre for Environmental Health, Neuherberg, Germany. 3. Dr von Hauner Children's Hospital, Ludwig-Maximilians-University Munich, Munich, Germany. 4. Department of Preventive and Paediatric Dentistry, Friedrich-Schiller-University of Jena, Jena, Germany. 5. Department of Operative Dentistry and Periodontology, Albert-Ludwigs-University of Freiburg, Freiburg, Germany. 6. Department of Conservative Dentistry and Periodontology, School of Dentistry, Ludwig-Maximilians-University of Munich, Goethestraße70, 80336, Munich, Germany.
Abstract
OBJECTIVE: We examined whether fluoride/vitamin D supplementation in the first year of life is associated with caries or molar incisor hypomineralization (MIH) at 10 years of age. METHODS: The study population consisted of 406 children for whom information on fluoride/vitamin D supplementation during the first year of life was available. Dental examination at the age of 10 included caries and MIH registration. The results of logistic regression models were adjusted for gender, age, BMI, parental education, and equivalent income. RESULTS: Children receiving supplementation during the entire first year of life had a significantly lower probability of having caries-related restorations in primary teeth in comparison to those who received supplementation for less than 6 months (fluoride supplementation: odds ratio (OR) for d3-4mfs 2.47 (1.32-4.63), for fs 2.70 (1.43-5.10); vitamin D supplementation: OR for d3-4mfs 2.08 (1.00-4.32), fs 2.50 (1.19-5.25)). The majority of logistic regression analyses indicated no association between supplementation and MIH. CONCLUSIONS: It was found a consistent significant caries-preventive effect in the primary dentition of children who received fluoride (256/372)/vitamin D supplementation (274/376) in all 12 months over the first year of life; no effects were observed for permanent dentition. The high parental interest in supplementation is linked to an imbalance of the study groups. Furthermore, tooth brushing frequency, use of fluoride toothpastes and/or other oral hygiene products were not recorded during the observation period which may also confound the results. CLINICAL RELEVANCE: Fluoride/vitamin D supplementation can be used in children for preventing caries in the primary dentition.
OBJECTIVE: We examined whether fluoride/vitamin D supplementation in the first year of life is associated with caries or molar incisor hypomineralization (MIH) at 10 years of age. METHODS: The study population consisted of 406 children for whom information on fluoride/vitamin D supplementation during the first year of life was available. Dental examination at the age of 10 included caries and MIH registration. The results of logistic regression models were adjusted for gender, age, BMI, parental education, and equivalent income. RESULTS:Children receiving supplementation during the entire first year of life had a significantly lower probability of having caries-related restorations in primary teeth in comparison to those who received supplementation for less than 6 months (fluoride supplementation: odds ratio (OR) for d3-4mfs 2.47 (1.32-4.63), for fs 2.70 (1.43-5.10); vitamin D supplementation: OR for d3-4mfs 2.08 (1.00-4.32), fs 2.50 (1.19-5.25)). The majority of logistic regression analyses indicated no association between supplementation and MIH. CONCLUSIONS: It was found a consistent significant caries-preventive effect in the primary dentition of children who received fluoride (256/372)/vitamin D supplementation (274/376) in all 12 months over the first year of life; no effects were observed for permanent dentition. The high parental interest in supplementation is linked to an imbalance of the study groups. Furthermore, tooth brushing frequency, use of fluoride toothpastes and/or other oral hygiene products were not recorded during the observation period which may also confound the results. CLINICAL RELEVANCE: Fluoride/vitamin D supplementation can be used in children for preventing caries in the primary dentition.
Entities:
Keywords:
Birth cohort study; Caries prevention; Epidemiology; Fluoride lozenges; Fluoride supplementation; Fluoride tablets; Prevention; Vitamin D supplementation; Vitamin D tablet
Authors: J Heinrich; G Bolte; B Hölscher; J Douwes; I Lehmann; B Fahlbusch; W Bischof; M Weiss; M Borte; H E Wichmann Journal: Eur Respir J Date: 2002-09 Impact factor: 16.671
Authors: Maria Grazia Cagetti; Thomas Gerhard Wolf; Christian Tennert; Nicole Camoni; Peter Lingström; Guglielmo Campus Journal: Int J Environ Res Public Health Date: 2020-02-03 Impact factor: 3.390
Authors: Angela Pia Cazzolla; Michele Di Cosola; Andrea Ballini; Luigi Santacroce; Roberto Lovero; Nunzio Francesco Testa; Vitantonio Lacarbonara; Annarosa De Franco; Giuseppe Troiano; Stefania Cantore; Mariasevera Di Comite; Riccardo Nocini; Lorenzo Lo Muzio; Vito Crincoli; Mario Dioguardi Journal: Biomed Res Int Date: 2021-10-29 Impact factor: 3.411