Harvi F Hart1,2, Christian J Barton2, Karim M Khan1, Henrik Riel3, Kay M Crossley2. 1. Centre for Hip Health and Mobility, University of British Columbia, Vancouver, British Columbia, Canada. 2. La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, La Trobe University, Bundoora, Victoria, Australia. 3. Research Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Abstract
BACKGROUND: Patellofemoral pain (PFP) occurs frequently, and may be related to patellofemoral osteoarthritis (PFOA). Obesity is associated with increased risk of knee OA. This systematic review involves a meta-regression and analysis to determine the relationship between body mass index (BMI) and PFP and PFOA, and to determine the link between BMI and interventional outcomes. METHODS: We searched seven electronic databases and reference lists of relevant papers and systematic reviews, for cross-sectional, prospective, human-based observational and interventional studies reporting BMI in individuals with PFP or PFOA compared to healthy controls. Two independent reviewers appraised methodological quality (epidemiological appraisal instrument). Where possible, data from prospective studies were pooled to conduct meta-regression and case-control, and intervention studies to conduct meta-analysis using the following categories: adolescents with PFP, adults with PFP and PFOA. RESULTS: 52 studies were included. We found greater BMI in adults with PFP (standardised mean difference: 0.24, 95% CI 0.12 to 0.36) and PFOA (0.73, 0.46 to 0.99) compared to healthy controls, but not in adolescents with PFP (-0.19, -0.56 to 0.18). We also observed statistical trends (p<0.10) towards higher BMI being a predictor for development of PFP in adults (0.34, -0.04 to 0.71). No significant link between BMI and intervention outcomes in adults with PFP was identified. CONCLUSIONS: Higher BMI is present in PFP and PFOA, but not in adolescents with PFP. PROSPERO REGISTRATION NUMBER: CRD42015024812. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
BACKGROUND:Patellofemoral pain (PFP) occurs frequently, and may be related to patellofemoral osteoarthritis (PFOA). Obesity is associated with increased risk of knee OA. This systematic review involves a meta-regression and analysis to determine the relationship between body mass index (BMI) and PFP and PFOA, and to determine the link between BMI and interventional outcomes. METHODS: We searched seven electronic databases and reference lists of relevant papers and systematic reviews, for cross-sectional, prospective, human-based observational and interventional studies reporting BMI in individuals with PFP or PFOA compared to healthy controls. Two independent reviewers appraised methodological quality (epidemiological appraisal instrument). Where possible, data from prospective studies were pooled to conduct meta-regression and case-control, and intervention studies to conduct meta-analysis using the following categories: adolescents with PFP, adults with PFP and PFOA. RESULTS: 52 studies were included. We found greater BMI in adults with PFP (standardised mean difference: 0.24, 95% CI 0.12 to 0.36) and PFOA (0.73, 0.46 to 0.99) compared to healthy controls, but not in adolescents with PFP (-0.19, -0.56 to 0.18). We also observed statistical trends (p<0.10) towards higher BMI being a predictor for development of PFP in adults (0.34, -0.04 to 0.71). No significant link between BMI and intervention outcomes in adults with PFP was identified. CONCLUSIONS: Higher BMI is present in PFP and PFOA, but not in adolescents with PFP. PROSPERO REGISTRATION NUMBER: CRD42015024812. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.
Authors: Harvi F Hart; Marienke van Middelkoop; Joshua J Stefanik; Kay M Crossley; Sita Bierma-Zeinstra Journal: Rheumatol Int Date: 2019-11-08 Impact factor: 2.631
Authors: Farhad Pishgar; Ali Guermazi; Amir Ashraf-Ganjouei; Arya Haj-Mirzaian; Frank W Roemer; Bashir Zikria; Christopher Sereni; Michael Hakky; Shadpour Demehri Journal: Skeletal Radiol Date: 2021-03-08 Impact factor: 2.199
Authors: Sara D Pullen; Carlos Del Rio; Daniel Brandon; Ann Colonna; Meredith Denton; Matthew Ina; Grace Lancaster; Anne-Grace Schmidtke; Vincent C Marconi Journal: AIDS Care Date: 2019-09-17
Authors: Erika K Zambarano; David M Bazett-Jones; Danilo de Oliveira Silva; Christian J Barton; Neal R Glaviano Journal: J Athl Train Date: 2022-01-01 Impact factor: 2.860
Authors: Erin M Macri; Agnes G d'Entremont; Kay M Crossley; Harvi F Hart; Bruce B Forster; David R Wilson; Charles R Ratzlaff; Charlie H Goldsmith; Karim M Khan Journal: J Orthop Res Date: 2019-03-01 Impact factor: 3.494