BACKGROUND: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP). STUDY DESIGN: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study. We determined CRP, PCT and P-SEP at admission, and then at 12, 24, and 48 h of age. Neonates recruited into the study were divided into the EOS group (n = 32) and the uninfected group (n =38) according to their infection screening. RESULTS: P-SEP values were significantly higher in the EOS group than in the uninfected group at different time intervals. The highest accuracy was achieved by P-SEP at 24 h after birth. The AUC for P-SEP was 0.97. In our sample, P-SEP achieved the best accuracy for prediction of EOS at the cut-off of 788 ng/l with 93% sensitivity and 100% specificity. CONCLUSIONS: This study shows that P-SEP is significantly higher in preterm infants with EOS compared with uninfected infants.
BACKGROUND: Early-onset sepsis (EOS) is responsible for an important fraction of neonatal morbidity and mortality all over the world. The aim of this study was to assess whether presepsin (P-SEP) can be a more accurate biomarker of EOS compared with pro-calcitonin (PCT) and C-reactive protein (CRP). STUDY DESIGN: Consecutive preterm neonates (<34 wk gestational age, admitted to Neonatal Intensive Care Unit by 6 h of age and undergoing sepsis evaluation) were recruited as part of a case-matched control study. We determined CRP, PCT and P-SEP at admission, and then at 12, 24, and 48 h of age. Neonates recruited into the study were divided into the EOS group (n = 32) and the uninfected group (n =38) according to their infection screening. RESULTS: P-SEP values were significantly higher in the EOS group than in the uninfected group at different time intervals. The highest accuracy was achieved by P-SEP at 24 h after birth. The AUC for P-SEP was 0.97. In our sample, P-SEP achieved the best accuracy for prediction of EOS at the cut-off of 788 ng/l with 93% sensitivity and 100% specificity. CONCLUSIONS: This study shows that P-SEP is significantly higher in preterm infants with EOS compared with uninfected infants.
Authors: N Modi; C J Doré; A Saraswatula; M Richards; K B Bamford; R Coello; A Holmes Journal: Arch Dis Child Fetal Neonatal Ed Date: 2008-05-22 Impact factor: 5.747
Authors: Evridiki K Vouloumanou; Eleni Plessa; Drosos E Karageorgopoulos; Elpis Mantadakis; Matthew E Falagas Journal: Intensive Care Med Date: 2011-03-05 Impact factor: 17.440
Authors: Samuel Asamoah Sakyi; Anthony Enimil; David Kwabena Adu; Richard Dadzie Ephraim; Kwabena Owusu Danquah; Linda Fondjo; David Baidoe-Ansah; Prince Adoba; Emmanuel Toboh; Bright Oppong Afranie Journal: Heliyon Date: 2020-09-14