PURPOSE: We aimed to assess the role of computed tomography (CT) perfusion in differentiation of thymoma from thymic hyperplasia, lymphoma, thymic carcinoma, and lung cancer invading anterior mediastinum. METHODS: In this study, 25 patients with an anterior mediastinal lesion underwent CT perfusion imaging from January 2015 to February 2016. Diagnoses included thymoma (n=7), thymic hyperplasia (n=8), lymphoma (n=4), thymic carcinoma (n=3), and invasive lung cancer (n=3). Lymphoma, thymic carcinoma, and lung cancer were grouped as malignant tumors for statistical analysis. Values for blood flow, blood volume, and permeability surface were measured in CT perfusion. RESULTS: Blood flow and blood volume values were higher in thymoma in comparison to thymic hyperplasia; however, the difference was not statistically significant. Blood volume values were significantly higher in thymoma (mean, 11.4 mL/100 mL; range, 5.2-20.2 mL/100 mL) compared with lymphoma (mean, 5.3 mL/100 mL; range, 2.5-7.2 mL/100 mL) (P = 0.023). Blood flow and blood volume values were significantly higher in thymoma compared with non-thymoma malignant tumors (P = 0.025). CONCLUSION: CT perfusion is helpful in differentiating thymoma from non-thymoma malignancies including lymphoma, thymic carcinoma, and invasive lung cancer involving the anterior mediastinum.
PURPOSE: We aimed to assess the role of computed tomography (CT) perfusion in differentiation of thymoma from thymic hyperplasia, lymphoma, thymic carcinoma, and lung cancer invading anterior mediastinum. METHODS: In this study, 25 patients with an anterior mediastinal lesion underwent CT perfusion imaging from January 2015 to February 2016. Diagnoses included thymoma (n=7), thymic hyperplasia (n=8), lymphoma (n=4), thymic carcinoma (n=3), and invasive lung cancer (n=3). Lymphoma, thymic carcinoma, and lung cancer were grouped as malignant tumors for statistical analysis. Values for blood flow, blood volume, and permeability surface were measured in CT perfusion. RESULTS: Blood flow and blood volume values were higher in thymoma in comparison to thymic hyperplasia; however, the difference was not statistically significant. Blood volume values were significantly higher in thymoma (mean, 11.4 mL/100 mL; range, 5.2-20.2 mL/100 mL) compared with lymphoma (mean, 5.3 mL/100 mL; range, 2.5-7.2 mL/100 mL) (P = 0.023). Blood flow and blood volume values were significantly higher in thymoma compared with non-thymoma malignant tumors (P = 0.025). CONCLUSION: CT perfusion is helpful in differentiating thymoma from non-thymoma malignancies including lymphoma, thymic carcinoma, and invasive lung cancer involving the anterior mediastinum.
Authors: H Yabuuchi; Y Matsuo; K Abe; S Baba; S Sunami; T Kamitani; M Yonezawa; Y Yamasaki; S Kawanami; M Nagao; T Okamoto; K Nakamura; H Yamamoto; M Sasaki; H Honda Journal: Clin Radiol Date: 2015-08-10 Impact factor: 2.350
Authors: Kyung Eun Shin; Chin A Yi; Tae Sung Kim; Ho Yun Lee; Young Soo Choi; Hong Kwan Kim; Jhingook Kim Journal: Eur Radiol Date: 2013-11-01 Impact factor: 5.315
Authors: Jeanne B Ackman; Stacey Verzosa; Alexandra E Kovach; Abner Louissaint; Michael Lanuti; Cameron D Wright; Jo-Anne O Shepard; Elkan F Halpern Journal: Eur J Radiol Date: 2014-12-13 Impact factor: 3.528
Authors: T Higuchi; J Taki; S Kinuya; M Yamada; M Kawasuji; O Matsui; A Nonomura; H Bunko; N Tonami Journal: Radiology Date: 2001-10 Impact factor: 11.105