Lalit Kishore 1 , Navpreet Kaur 1 , Randhir Singh 1 Show Affiliations »
Abstract
BACKGROUND: Diabetic nephropathy (DN) is one of the foremost causes of mortality in diabetic patients as a result of increased urinary albumin excretion (UAE) rate and compromised renal function. INTRODUCTION: Determination of increased excretion of albumin in urine chiefly attribute to the onset and progression of DN. However, due to certain limitations of albuminuria, the search for more sensitive, specific and reliable renal biomarkers is required for early prediction of DN. METHODS: Bibliographic investigation was made to scrutinize the data reporting relevant biomarkers associated with DN and may be used to predict the onset and progression of nephropathy. RESULT AND CONCLUSION: Optimization of biomarkers for a clinical situation requires a prospective validation in large numbers of patients with diabetic nephropathy and needs to be performed in different critically ill populations. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Diabetic nephropathy (DN) is one of the foremost causes of mortality in diabetic patients as a result of increased urinary albumin excretion (UAE) rate and compromised renal function. INTRODUCTION: Determination of increased excretion of albumin in urine chiefly attribute to the onset and progression of DN. However, due to certain limitations of albuminuria , the search for more sensitive, specific and reliable renal biomarkers is required for early prediction of DN. METHODS: Bibliographic investigation was made to scrutinize the data reporting relevant biomarkers associated with DN and may be used to predict the onset and progression of nephropathy . RESULT AND CONCLUSION: Optimization of biomarkers for a clinical situation requires a prospective validation in large numbers of patients with diabetic nephropathy and needs to be performed in different critically ill populations. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities: Disease
Species
Keywords:
Albuminuria; albumin; biomarkers; diabetic nephropathy; diagnostic method; emerging biomarkers
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Year: 2017
PMID： 27924722 DOI： 10.2174/1573399812666161207123007
Source DB: PubMed Journal: Curr Diabetes Rev ISSN： 1573-3998