Sapna Sharma1, Bageshree Seth2, Prashant Jawade3, Madhavi Ingale4, Maninder Singh Setia5. 1. Department of Pediatrics, Mahatma Gandhi Mission's Medical College, Sector -1, Kamothe, Navi-Mumbai, Maharashtra, 410209, India. 2. Department of Pediatrics, Mahatma Gandhi Mission's Medical College, Sector -1, Kamothe, Navi-Mumbai, Maharashtra, 410209, India. bageshrees@rediffmail.com. 3. Navi-Mumbai Municipal Corporation General Hospital, Sector 10A, Vashi, Navi-Mumbai, Maharashtra, India. 4. Thalassemia Day Care Centre, Navi-Mumbai Municipal Corporation General Hospital, Sector 10A, Vashi, Navi-Mumbai, Maharashtra, India. 5. MGM Institute of Health Sciences, Sector -1, Kamothe, Navi-Mumbai, Maharashtra, India.
Abstract
OBJECTIVES: To assess and compare the Quality of Life (QOL) of children with beta-thalassemia major on regular transfusion therapy with normal children, and of the caregivers of children with beta-thalassemia major to that of caregivers of normal children. METHODS: A cross-sectional comparison of QOL in 75 thalassemic and 80 non-thalassemic children was conducted using the PedsQL™ 4.0 generic core scale. Also self-rated health was assessed in their caregivers using Short Form-36 Health Survey. RESULTS: The total QOL score according to child-self report [83.7 (10.8) vs. 97.6 (3.3); p < 0.001] and parent-proxy report [84.2 (11.9) vs. 96.7 (3.5); p < 0.001] was significantly lower in cases as compared with controls. It was found that a significantly higher proportion of caregivers of cases reported poor health compared with caregivers of controls (29.2% vs. 2.5%, p < 0.001). Even after adjusting for age, sex, socio-economic status, and total QOL score by the parent, it was found that caregivers of thalassemic children were significantly more likely to report poor health compared with those of controls (odds ratio: 15.8, 95% confidence intervals: 2.8-89.9). CONCLUSIONS: Health Related QOL is significantly affected in children with beta-thalassemia major on regular transfusion across all age groups, gender and socio-economic classes and also in their caregivers.
OBJECTIVES: To assess and compare the Quality of Life (QOL) of children with beta-thalassemia major on regular transfusion therapy with normal children, and of the caregivers of children with beta-thalassemia major to that of caregivers of normal children. METHODS: A cross-sectional comparison of QOL in 75 thalassemic and 80 non-thalassemic children was conducted using the PedsQL™ 4.0 generic core scale. Also self-rated health was assessed in their caregivers using Short Form-36 Health Survey. RESULTS: The total QOL score according to child-self report [83.7 (10.8) vs. 97.6 (3.3); p < 0.001] and parent-proxy report [84.2 (11.9) vs. 96.7 (3.5); p < 0.001] was significantly lower in cases as compared with controls. It was found that a significantly higher proportion of caregivers of cases reported poor health compared with caregivers of controls (29.2% vs. 2.5%, p < 0.001). Even after adjusting for age, sex, socio-economic status, and total QOL score by the parent, it was found that caregivers of thalassemic children were significantly more likely to report poor health compared with those of controls (odds ratio: 15.8, 95% confidence intervals: 2.8-89.9). CONCLUSIONS: Health Related QOL is significantly affected in children with beta-thalassemia major on regular transfusion across all age groups, gender and socio-economic classes and also in their caregivers.
Entities:
Keywords:
Caregivers; Peds QOL generic core scale; Quality of life; Thalassemia
Authors: Mohammed D Ayoub; Suhaib A Radi; Abdulrahman M Azab; Abdulrahman A Abulaban; Abdulrahman H Balkhoyor; Seifeleslam W Bedair; Soad K Aljaouni; Jameela A Kari Journal: Saudi Med J Date: 2013-12 Impact factor: 1.484
Authors: Abdulqadir J Nashwan; Mohamed A Yassin; Ganga Devi J Babu; Sindhumole L K Nair; Izette L Libo-On; Hothaifah A Hijazi; Vincenzo De Sanctis; Ashraf Soliman Journal: Acta Biomed Date: 2018-02-16