Literature DB >> 27924322

A Cu(ii) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights.

D Montagner1, B Fresch2, K Browne3, V Gandin4, A Erxleben3.   

Abstract

A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 27924322     DOI： 10.1039/c6cc08100b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Syntheses and Biological Studies of Cu(II) Complexes Bearing Bis(pyrazol-1-yl)- and Bis(triazol-1-yl)-acetato Heteroscorpionate Ligands.

Authors:  Maura Pellei; Valentina Gandin; Luciano Marchiò; Cristina Marzano; Luca Bagnarelli; Carlo Santini
Journal:  Molecules       Date:  2019-05-07       Impact factor: 4.411

2.  Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist.

Authors:  Maura Pellei; Luca Bagnarelli; Lorenzo Luciani; Fabio Del Bello; Gianfabio Giorgioni; Alessandro Piergentili; Wilma Quaglia; Michele De Franco; Valentina Gandin; Cristina Marzano; Carlo Santini
Journal:  Int J Mol Sci       Date:  2020-04-09       Impact factor: 5.923

Review 3.  Emergent Nanotechnological Strategies for Systemic Chemotherapy against Melanoma.

Authors:  Jacinta Oliveira Pinho; Mariana Matias; Maria Manuela Gaspar
Journal:  Nanomaterials (Basel)       Date:  2019-10-13       Impact factor: 5.076

4.  Cu(I) and Cu(II) Complexes Based on Lonidamine-Conjugated Ligands Designed to Promote Synergistic Antitumor Effects.

Authors:  Fabio Del Bello; Maura Pellei; Luca Bagnarelli; Carlo Santini; Gianfabio Giorgioni; Alessandro Piergentili; Wilma Quaglia; Chiara Battocchio; Giovanna Iucci; Irene Schiesaro; Carlo Meneghini; Iole Venditti; Nitya Ramanan; Michele De Franco; Paolo Sgarbossa; Cristina Marzano; Valentina Gandin
Journal:  Inorg Chem       Date:  2022-03-14       Impact factor: 5.165
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.