Navjot Chaudhary1, Jennifer S Lee2, Joy Y Wu3, Suzanne Tharin4. 1. Department of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA; Department of Neurosurgery, Veterans Affairs Hospital, Palo Alto, California, USA. Electronic address: navjotc@stanford.edu. 2. Cooperative Studies Program Coordinating Center, Veterans Affairs Hospital, Palo Alto, California, USA; Division of Endocrinology, School of Medicine, Stanford University, Stanford, California, USA. 3. Division of Endocrinology, School of Medicine, Stanford University, Stanford, California, USA. 4. Department of Neurosurgery, School of Medicine, Stanford University, Stanford, California, USA; Department of Neurosurgery, Veterans Affairs Hospital, Palo Alto, California, USA.
Abstract
BACKGROUND: Osteoporosis is defined as bone mineral density. METHODS: A PubMed literature review was performed to review preclinical and clinical evidence for the use of teriparatide in osteoporotic patients undergoing spine fusion surgery. RESULTS: Preclinical studies in animal models show that teriparatide increases spinal fusion rates. Early clinical studies show that teriparatide both increases spinal fusion rates and decreases hardware loosening in the setting of postmenopausal osteoporosis. CONCLUSION: Ongoing additional trials will help formulate preoperative screening recommendations, determine the optimal duration of preoperative and postoperative teriparatide treatment, and investigate its utility in men.
BACKGROUND:Osteoporosis is defined as bone mineral density. METHODS: A PubMed literature review was performed to review preclinical and clinical evidence for the use of teriparatide in osteoporoticpatients undergoing spine fusion surgery. RESULTS: Preclinical studies in animal models show that teriparatide increases spinal fusion rates. Early clinical studies show that teriparatide both increases spinal fusion rates and decreases hardware loosening in the setting of postmenopausal osteoporosis. CONCLUSION: Ongoing additional trials will help formulate preoperative screening recommendations, determine the optimal duration of preoperative and postoperative teriparatide treatment, and investigate its utility in men.
Authors: Min Soo Jang; Jong Bin Park; Kang Hoon Lee; Ji Yun Jang; Myeong Hyeon Yang; Joon Hee Kim; Hyun Hwangbo; Taek Geun Lee; Kee Suck Suh Journal: Ann Dermatol Date: 2017-12-26 Impact factor: 1.444
Authors: Nikhil Jain; Lawal Labaran; Frank M Phillips; Safdar N Khan; Amit Jain; Khaled M Kebaish; Hamid Hassanzadeh Journal: Global Spine J Date: 2020-12-17