OBJECTIVES: To describe sleep EEG patterns of neonates, and infants with microcephaly due to congenital Zika virus (ZikV) syndrome. METHODS: A descriptive case series of EEGs performed in a cohort of neonates with microcephaly monitored from October 2015 to February 2016 at a University Hospital in Northeast Brazil. Infants were investigated following an established protocol that includes EEG, neuroimaging studies, PCR and specific antibodies for ZikV detection. RESULTS: EEGs (n=37) from 37 infants were reviewed. Age at investigation varied from 1 to 5months (mean=2.6). Diffuse low voltage (n=7), background asymmetry (n=6) and modified hypsarrhythmia with or without burst-suppression (n=11), were the main background abnormalities identified. Interictal EEG abnormalities were identified in 23 recordings (62%) and localized as focal frontal (n=8) or occipital (n=2) spikes/sharp, multifocal spikes/sharp waves (n=13). Electrographic seizures without clinical manifestation were identified in 4 recordings and characterized as focal pseudo rhythmic pattern. Further findings were focal high amplitude slow waves that were registered in the frontal (n=3) or occipital (n=1) regions. CONCLUSIONS: Different types of EEG abnormalities were encountered with a predominance of interictal epileptogenic activity and hypsarrhythmia. SIGNIFICANCE: Sleep EEGs in congenital Zika virus syndrome are consistently abnormal even in infants who have not yet developed epilepsy.
OBJECTIVES: To describe sleep EEG patterns of neonates, and infants with microcephaly due to congenital Zika virus (ZikV) syndrome. METHODS: A descriptive case series of EEGs performed in a cohort of neonates with microcephaly monitored from October 2015 to February 2016 at a University Hospital in Northeast Brazil. Infants were investigated following an established protocol that includes EEG, neuroimaging studies, PCR and specific antibodies for ZikV detection. RESULTS: EEGs (n=37) from 37 infants were reviewed. Age at investigation varied from 1 to 5months (mean=2.6). Diffuse low voltage (n=7), background asymmetry (n=6) and modified hypsarrhythmia with or without burst-suppression (n=11), were the main background abnormalities identified. Interictal EEG abnormalities were identified in 23 recordings (62%) and localized as focal frontal (n=8) or occipital (n=2) spikes/sharp, multifocal spikes/sharp waves (n=13). Electrographic seizures without clinical manifestation were identified in 4 recordings and characterized as focal pseudo rhythmic pattern. Further findings were focal high amplitude slow waves that were registered in the frontal (n=3) or occipital (n=1) regions. CONCLUSIONS: Different types of EEG abnormalities were encountered with a predominance of interictal epileptogenic activity and hypsarrhythmia. SIGNIFICANCE: Sleep EEGs in congenital Zika virus syndrome are consistently abnormal even in infants who have not yet developed epilepsy.
Authors: Jamary Oliveira-Filho; Ridalva Felzemburgh; Federico Costa; Nivison Nery; Adriana Mattos; Daniele F Henriques; Albert I Ko Journal: Am J Trop Med Hyg Date: 2018-04-19 Impact factor: 2.345
Authors: Rahul Mittal; Desiree Nguyen; Luca H Debs; Amit P Patel; George Liu; Vasanti M Jhaveri; Sae-In S Kay; Jeenu Mittal; Emmalee S Bandstra; Ramzi T Younis; Prem Chapagain; Dushyantha T Jayaweera; Xue Zhong Liu Journal: Front Cell Infect Microbiol Date: 2017-12-08 Impact factor: 5.293
Authors: Tolulope Adebanjo; Shana Godfred-Cato; Laura Viens; Marc Fischer; J Erin Staples; Wendi Kuhnert-Tallman; Henry Walke; Titilope Oduyebo; Kara Polen; Georgina Peacock; Dana Meaney-Delman; Margaret A Honein; Sonja A Rasmussen; Cynthia A Moore Journal: MMWR Morb Mortal Wkly Rep Date: 2017-10-20 Impact factor: 17.586
Authors: Joseph Darbellay; Brian Cox; Kenneth Lai; Mario Delgado-Ortega; Colette Wheler; Donald Wilson; Stewart Walker; Gregory Starrak; Duncan Hockley; Yanyun Huang; George Mutwiri; Andrew Potter; Matthew Gilmour; David Safronetz; Volker Gerdts; Uladzimir Karniychuk Journal: EBioMedicine Date: 2017-09-21 Impact factor: 8.143
Authors: Anne C Wheeler; Camila V Ventura; Ty Ridenour; Danielle Toth; Lucélia Lima Nobrega; Lana Claudia Silva de Souza Dantas; Camilla Rocha; Donald B Bailey; Liana O Ventura Journal: PLoS One Date: 2018-07-26 Impact factor: 3.240