Literature DB >> 27923186

Influence of surface passivation of 2-Methoxyestradiol loaded PLGA nanoparticles on cellular interactions, pharmacokinetics and tumour accumulation.

Gopikrishna J Pillai1, Bindhu Paul-Prasanth1, Shantikumar V Nair2, Deepthy Menon3.   

Abstract

In the present work, 2-Methoxyestradiol [2ME2] loaded PLGA nanoparticles [NPs] were stabilized with Casein or poly(ethylene glycol) [PEG] and evaluated for its cellular interactions, pharmacokinetics and tumour accumulation. Surface stabilized PLGA nanoparticles prepared through a modified emulsion route possessed similar size, surface charge, drug loading and release characteristics. Particle-cell interactions as well as the anti-angiogenesis activity were similar for both nanoformulations in vitro. However, in vivo pharmacokinetics and tumour accumulation of the drug were substantially improved for the PEGylated nanoformulation. Reduced protein binding was observed for PEG stabilized PLGA NPs. Thus, it was demonstrated that nanoencapsulation of 2-ME2 within PEGylated PLGA nanocarrier could improve its half-life and plasma concentration and thereby increase the tumour accumulation.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  2-Methoxyestradiol; Breast cancer; Drug delivery; PLGA nanoparticles; Pharmacokinetics; Protein binding; Tumour accumulation

Mesh：

Substances：

Year:  2016        PMID： 27923186     DOI： 10.1016/j.colsurfb.2016.11.040

Source DB:  PubMed          Journal:  Colloids Surf B Biointerfaces        ISSN： 0927-7765            Impact factor:   5.268


  6 in total

1.  Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification.

Authors:  Linmei Pan; Jing Zhou; Feng Ju; Huaxu Zhu
Journal:  Drug Deliv Transl Res       Date:  2018-02       Impact factor: 4.617

2.  Optimized 2-methoxyestradiol invasomes fortified with apamin: a promising approach for suppression of A549 lung cancer cells.

Authors:  Zuhier A Awan; Shareefa A AlGhamdi; Nabil A Alhakamy; Solomon Z Okbazghi; Mohamed A Alfaleh; Shaimaa M Badr-Eldin; Hibah M Aldawsari; Mohammed A S Abourehab; Hani Z Asfour; Shadi A Zakai; Mohammad W Alrabia; Aya A Negm; Mohamed A El-Moselhy; Sara S Sharkawi; Waleed Y Rizg
Journal:  Drug Deliv       Date:  2022-12       Impact factor: 6.819

3.  Phagocytosis of polymeric nanoparticles aided activation of macrophages to increase atherosclerotic plaques in ApoE-/- mice.

Authors:  Tieying Yin; Yanhong Li; Yuzhen Ren; Atik Rohmana Maftuhatul Fuad; Fangfang Hu; Ruolin Du; Yang Wang; Guixue Wang; Yazhou Wang
Journal:  J Nanobiotechnology       Date:  2021-04-28       Impact factor: 10.435

4.  2-Methoxy-estradiol Loaded Alpha Lipoic Acid Nanoparticles Augment Cytotoxicity in MCF-7 Breast Cancer Cells.

Authors:  Nabil A Alhakamy; Mohammed W Al-Rabia; Hani Z Asfour; Samah Alshehri; Waleed S Alharbi; Abdulrahman Halawani; Abdulmohsin J Alamoudi; Ahmad O Noor; Douha F Bannan; Usama A Fahmy; Sabna Kotta
Journal:  Dose Response       Date:  2021-12-09       Impact factor: 2.658

5.  2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis.

Authors:  Mohammed W Al-Rabia; Mohamed A Alfaleh; Hani Z Asfour; Waleed S Alharbi; Mohamed A El-Moselhy; Nabil A Alhakamy; Usama A Fahmy; Osama A A Ahmed; Omar Fahmy; Omar M Rashad; Abdulmohsin J Alamoudi; Ashraf B Abdel-Naim
Journal:  Antioxidants (Basel)       Date:  2022-07-30

Review 6.  In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

Authors:  Nimisha Singh; Célia Marets; Julien Boudon; Nadine Millot; Lucien Saviot; Lionel Maurizi
Journal:  Nanoscale Adv       Date:  2021-01-13
  6 in total

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