Literature DB >> 27921096

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo.

X Luo1, W Wang2, J R Dorkin3, O Veiseh4, P H Chang2, I Abutbul-Ionita5, D Danino5, R Langer6, D G Anderson6, Y Dong7.   

Abstract

Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously.

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Year:  2016        PMID： 27921096      PMCID： PMC5216453          DOI： 10.1039/c6bm00683c

Source DB:  PubMed          Journal:  Biomater Sci        ISSN： 2047-4830            Impact factor:   6.843


  24 in total

1.  Highly Efficient SiRNA Delivery Mediated by Cationic Helical Polypeptides and Polypeptide-Based Nanosystems.

Authors:  Lichen Yin; Nan Zheng; Jianjun Cheng
Journal:  Methods Mol Biol       Date:  2016

Review 2.  Safety profile of RNAi nanomedicines.

Authors:  Scott A Barros; Jared A Gollob
Journal:  Adv Drug Deliv Rev       Date:  2012-06-22       Impact factor: 15.470

3.  Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates.

Authors:  Yizhou Dong; Kevin T Love; J Robert Dorkin; Sasilada Sirirungruang; Yunlong Zhang; Delai Chen; Roman L Bogorad; Hao Yin; Yi Chen; Arturo J Vegas; Christopher A Alabi; Gaurav Sahay; Karsten T Olejnik; Weiheng Wang; Avi Schroeder; Abigail K R Lytton-Jean; Daniel J Siegwart; Akin Akinc; Carmen Barnes; Scott A Barros; Mary Carioto; Kevin Fitzgerald; Julia Hettinger; Varun Kumar; Tatiana I Novobrantseva; June Qin; William Querbes; Victor Koteliansky; Robert Langer; Daniel G Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-10       Impact factor: 11.205

4.  In vivo delivery of nucleic acids via glycopolymer vehicles affords therapeutic infarct size reduction in vivo.

Authors:  Michael Tranter; Yemin Liu; Suiwen He; James Gulick; Xiaoping Ren; Jeffrey Robbins; W Keith Jones; Theresa M Reineke
Journal:  Mol Ther       Date:  2011-12-20       Impact factor: 11.454

Review 5.  Current progress of siRNA/shRNA therapeutics in clinical trials.

Authors:  John C Burnett; John J Rossi; Katrin Tiemann
Journal:  Biotechnol J       Date:  2011-07-11       Impact factor: 4.677

Review 6.  Delivery of oligonucleotides with lipid nanoparticles.

Authors:  Yuhua Wang; Lei Miao; Andrew Satterlee; Leaf Huang
Journal:  Adv Drug Deliv Rev       Date:  2015-02-27       Impact factor: 15.470

7.  Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.

Authors:  Mark E Davis; Jonathan E Zuckerman; Chung Hang J Choi; David Seligson; Anthony Tolcher; Christopher A Alabi; Yun Yen; Jeremy D Heidel; Antoni Ribas
Journal:  Nature       Date:  2010-03-21       Impact factor: 49.962

8.  Lipid-coated polymeric nanoparticles for cancer drug delivery.

Authors:  Sangeetha Krishnamurthy; Rajendran Vaiyapuri; Liangfang Zhang; Juliana M Chan
Journal:  Biomater Sci       Date:  2015-02-11       Impact factor: 6.843

9.  The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic.

Authors:  Mark E Davis
Journal:  Mol Pharm       Date:  2009 May-Jun       Impact factor: 4.939

10.  An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo.

Authors:  Bin Li; Xiao Luo; Binbin Deng; Junfeng Wang; David W McComb; Yimin Shi; Karin M L Gaensler; Xu Tan; Amy L Dunn; Bryce A Kerlin; Yizhou Dong
Journal:  Nano Lett       Date:  2015-11-06       Impact factor: 11.189
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  1 in total

1.  Lipidoid-siRNA Nanoparticle-Mediated IL-1β Gene Silencing for Systemic Arthritis Therapy in a Mouse Model.

Authors:  Ping Song; Chuanxu Yang; Jesper Skovhus Thomsen; Frederik Dagnæs-Hansen; Maria Jakobsen; Annemarie Brüel; Bent Deleuran; Jørgen Kjems
Journal:  Mol Ther       Date:  2019-05-15       Impact factor: 11.454
  1 in total

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