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Literature DB >> 27920627

The Role of NSAIDs in Breast Cancer Prevention and Relapse: Current Evidence and Future Perspectives.

Demetrios Moris¹, Michalis Kontos¹, Eleftherios Spartalis¹, Ian S Fentiman².

Abstract

Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) have received considerable interest as potential chemopreventive agents. The aim of this review is to summarize the accumulated knowledge on the effect of NSAIDs on breast cancer incidence and natural history, and the underlying pathophysiology. NSAIDs mainly block inflammation by inhibiting cyclooxygenase enzymes, leading to lower prostaglandin synthesis. The latter has been reported to affect breast cancer risk through hormonal and inflammation-related pathways. Intensity, dose, frequency, duration, and timing of administration may also be significant. There is currently enough evidence to support a role of NSAIDs in breast cancer prevention and relapse, which deserves further large-scale experimental and clinical investigation.

Entities: Chemical Disease

Keywords: Aspirin; Breast cancer; Hormone receptors; NSAIDs; Prevention

Year: 2016 PMID： 27920627 PMCID： PMC5122986 DOI： 10.1159/000452315

Source DB: PubMed Journal: Breast Care (Basel) ISSN： 1661-3791 Impact factor: 2.860

62 in total

1. Nonsteroidal antiinflammatory drugs and breast cancer risk: the multiethnic cohort.

Authors: Jasmeet K Gill; Gertraud Maskarinec; Lynne R Wilkens; Malcolm C Pike; Brian E Henderson; Laurence N Kolonel
Journal: Am J Epidemiol Date: 2007-08-14 Impact factor: 4.897

Review 2. Use of common medications and breast cancer risk.

Authors: Kirsten B Moysich; Gregory P Beehler; Gary Zirpoli; Ji-Yeob Choi; Julie A Baker
Journal: Cancer Epidemiol Biomarkers Prev Date: 2008-07 Impact factor: 4.254

3. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.

Authors: Heather N Tinsley; Bernard D Gary; Adam B Keeton; Wei Zhang; Ashraf H Abadi; Robert C Reynolds; Gary A Piazza
Journal: Mol Cancer Ther Date: 2009-12 Impact factor: 6.261

4. Aspirin and other nonsteroidal anti-inflammatory drugs and breast cancer incidence in a large U.S. cohort.

Authors: Eric J Jacobs; Michael J Thun; Cari J Connell; Carmen Rodriguez; S Jane Henley; Heather S Feigelson; Alpa V Patel; W Dana Flanders; Eugenia E Calle
Journal: Cancer Epidemiol Biomarkers Prev Date: 2005-01 Impact factor: 4.254

5. HER-2/neu status is a determinant of mammary aromatase activity in vivo: evidence for a cyclooxygenase-2-dependent mechanism.

Authors: Kotha Subbaramaiah; Louise R Howe; Elisa R Port; Edi Brogi; Jack Fishman; Catherine H Liu; Timothy Hla; Clifford Hudis; Andrew J Dannenberg
Journal: Cancer Res Date: 2006-05-15 Impact factor: 12.701

Review 6. Aspirin, ibuprofen, and other non-steroidal anti-inflammatory drugs in cancer prevention: a critical review of non-selective COX-2 blockade (review).

Authors: Randall E Harris; Joanne Beebe-Donk; Hani Doss; Deborah Burr Doss
Journal: Oncol Rep Date: 2005-04 Impact factor: 3.906

Review 7. Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes.

Authors: Beth A Virnig; Todd M Tuttle; Tatyana Shamliyan; Robert L Kane
Journal: J Natl Cancer Inst Date: 2010-01-13 Impact factor: 13.506

Review 8. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement.

Authors: Jack Cuzick; Florian Otto; John A Baron; Powel H Brown; John Burn; Peter Greenwald; Janusz Jankowski; Carlo La Vecchia; Frank Meyskens; Hans Jörg Senn; Michael Thun
Journal: Lancet Oncol Date: 2009-05 Impact factor: 41.316

9. Regulation of HER-2 oncogene expression by cyclooxygenase-2 and prostaglandin E2.

Authors: Valérie Benoit; Biserka Relic; Xavier de Leval Xd; Alain Chariot; Marie-Paule Merville; Vincent Bours
Journal: Oncogene Date: 2004-02-26 Impact factor: 9.867

10. Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis.

Authors: Antonio González-Pérez; Luis A García Rodríguez; Ruy López-Ridaura
Journal: BMC Cancer Date: 2003-10-31 Impact factor: 4.430

14 in total

1. Indomethacin impairs mitochondrial dynamics by activating the PKCζ-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.

Authors: Somnath Mazumder; Rudranil De; Subhashis Debsharma; Samik Bindu; Pallab Maity; Souvik Sarkar; Shubhra Jyoti Saha; Asim Azhar Siddiqui; Chinmoy Banerjee; Shiladitya Nag; Debanjan Saha; Saikat Pramanik; Kalyan Mitra; Uday Bandyopadhyay
Journal: J Biol Chem Date: 2019-04-02 Impact factor: 5.157

2. High mammographic density in women is associated with protumor inflammation.

Authors: Cecilia W Huo; Prue Hill; Grace Chew; Paul J Neeson; Heloise Halse; Elizabeth D Williams; Michael A Henderson; Erik W Thompson; Kara L Britt
Journal: Breast Cancer Res Date: 2018-08-09 Impact factor: 6.466

3. Inhibition of SIRT1 deacetylase and p53 activation uncouples the anti-inflammatory and chemopreventive actions of NSAIDs.

Authors: Giulia Dell'Omo; Daniela Crescenti; Cristina Vantaggiato; Chiara Parravicini; Aurora Paola Borroni; Nicoletta Rizzi; Mariangela Garofalo; Andrea Pinto; Camilla Recordati; Eugenio Scanziani; Fabio Domenico Bassi; Giancarlo Pruneri; Paola Conti; Ivano Eberini; Adriana Maggi; Paolo Ciana
Journal: Br J Cancer Date: 2019-02-11 Impact factor: 7.640

4. A novel mechanism for the anticancer activity of aspirin and salicylates.

Authors: Asma'u I J Bashir; Chandra S Kankipati; Sarah Jones; Robert M Newman; Stephen T Safrany; Christopher J Perry; Iain D Nicholl
Journal: Int J Oncol Date: 2019-01-29 Impact factor: 5.650

5. Aspirin use and risk of breast cancer in African American women.

Authors: Kimberly A Bertrand; Traci N Bethea; Hanna Gerlovin; Patricia F Coogan; Lauren Barber; Lynn Rosenberg; Julie R Palmer
Journal: Breast Cancer Res Date: 2020-09-04 Impact factor: 6.466

6. α-Conotoxins and α-Cobratoxin Promote, while Lipoxygenase and Cyclooxygenase Inhibitors Suppress the Proliferation of Glioma C6 Cells.

Authors: Tatiana I Terpinskaya; Alexey V Osipov; Elena V Kryukova; Denis S Kudryavtsev; Nina V Kopylova; Tatsiana L Yanchanka; Alena F Palukoshka; Elena A Gondarenko; Maxim N Zhmak; Victor I Tsetlin; Yuri N Utkin
Journal: Mar Drugs Date: 2021-02-21 Impact factor: 5.118

10. Prospects of NSAIDs administration as double-edged agents against endometrial cancer and pathological species of the uterine microbiome.

Authors: Olga Kuźmycz; Paweł Stączek
Journal: Cancer Biol Ther Date: 2020-03-15 Impact factor: 4.742