| Literature DB >> 27920180 |
Adam D DeZure1, Nina M Berkowitz1, Barney S Graham1, Julie E Ledgerwood1.
Abstract
Chikungunya virus (CHIKV) is a global public health threat, having been identified in >60 countries in Asia, Africa, Europe, and the Americas. There is no cure for or licensed vaccine against CHIKV infection. Initial attempts at CHIKV vaccine development began in the early 1960s. Whole-inactivated and virus-like particle (VLP) vaccines are 2 of the current approaches being evaluated. Success of these approaches is dependent on a safe, well-tolerated vaccine that is immunogenic and deployable in regard to manufacturing, stability, and delivery characteristics. Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.Entities:
Keywords: alphavirus; chikungunya virus; vaccine; virus-like particle vaccine; whole-inactivated vaccine
Mesh:
Substances:
Year: 2016 PMID: 27920180 PMCID: PMC5137244 DOI: 10.1093/infdis/jiw352
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226