Yo-Ichi Yamashita1,2, Huanlin Wang3, Takeshi Kurihara3, Eiji Tsujita2, Akihiro Nishie4, Katsunori Imai5, Daisuke Hashimoto5, Akira Chikamoto5, Shinichi Aishima6, Hideo Baba5. 1. Department of Gastroenterological Surgery, Kumamoto University, Kumamoto, Japan y-yama@kumamoto-u.ac.jp. 2. Department of Hepato-Biliary-Pancreatic Surgery, National Kyushu Cancer Center, Fukuoka, Japan. 3. Department of Surgery and Science, Kyushu University, Fukuoka, Japan. 4. Department of Clinical Radiology, Kyushu University, Fukuoka, Japan. 5. Department of Gastroenterological Surgery, Kumamoto University, Kumamoto, Japan. 6. Department of Pathology and Microbiology, Saga University, Saga, Japan.
Abstract
BACKGROUND: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). PATIENTS AND METHODS: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. RESULTS: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9). The positive rates of pathological lymphatic infiltration (ly) (p=0.02) and perineural invasion (pn) (p<0.0001) were significantly higher in perihilar ICC. There was no significant difference in the disease-free survival rate (p=0.2268); however, the overall survival rate of perihilar ICC was significantly worse (p=0.0031). The rate of systemic recurrence (>3 nodules) was significantly higher in perihilar ICC (p=0.0135). CONCLUSION: In perihilar ICC, the local tumor invasions such as ly and pn were more frequent. Therefore, it is important in such cases to attempt to achieve a sufficient tumor margin. Systemic recurrences were more frequent in perihilar ICC, so perioperative chemotherapy should be conducted as well. Copyright
BACKGROUND: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). PATIENTS AND METHODS: A retrospective cohort study was performed to analyze the differences in clinical characteristics between perihilar and peripheral ICC samples from patients between 1990-2014. RESULTS: A total of 87 patients were divided into three ICC subtypes; perihilar (n=34), peripheral (n=44), and unclassifiable ICC (n=9). The positive rates of pathological lymphatic infiltration (ly) (p=0.02) and perineural invasion (pn) (p<0.0001) were significantly higher in perihilar ICC. There was no significant difference in the disease-free survival rate (p=0.2268); however, the overall survival rate of perihilar ICC was significantly worse (p=0.0031). The rate of systemic recurrence (>3 nodules) was significantly higher in perihilar ICC (p=0.0135). CONCLUSION: In perihilar ICC, the local tumor invasions such as ly and pn were more frequent. Therefore, it is important in such cases to attempt to achieve a sufficient tumor margin. Systemic recurrences were more frequent in perihilar ICC, so perioperative chemotherapy should be conducted as well. Copyright
Authors: Chung Hyeun Ma; Dae Wook Hwang; Ki Byung Song; Song Cheol Kim; Sang Hyun Shin; Jae Hoon Lee Journal: Ann Surg Treat Res Date: 2020-02-28 Impact factor: 1.859