Seong-Kyu Kim1, Jung-Yoon Choe1, Shin-Seok Lee2, Kichul Shin3. 1. a Department of Internal Medicine, Division of Rheumatology , Arthritis & Autoimmunity Research Center, Catholic University of Daegu School of Medicine , Daegu , South Korea. 2. b Department of Rheumatology , Chonnam National University Medical School , Gwangju , South Korea , and. 3. c Department of Internal Medicine, Division of Rheumatology , Seoul Metropolitan Government-Seoul National University Boramae Medical Center , Seoul , South Korea.
Abstract
OBJECTIVE: We investigated whether body mass index (BMI) is associated with parameters of disease activity and clinical manifestations in axial spondyloarthritis (axSpA). METHODS: Demographic, clinical, and radiological features and disease activity indexes from 789 axSpA patients (619 males and 170 females) were obtained from the Korean College of Rheumatology BIOlogics (KOBIO) registry. BMI (kg/m2) was classified into normal (BMI <23.0), overweight (23.0 ≤ BMI <25.0), and obese (BMI ≥25.0). Disease activity indexes included Bath ankylosing spondylitis disease activity index (BASDAI), erythrocyte sediment rate (ESR), C-reactive protein (CRP), and ankylosing spondylitis disease activity score (ASDAS). RESULTS: The mean BMI in patients with axSpA was 23.3 ± 3.5. 50.2% of all patients were overweight or obese. Overweight/obese patients had more syndesmophyte and less peripheral arthritis than those in normal BMI patients (p < 0.001 and p < 0.030, respectively). BMI was not associated with disease activity indexes in axSpA patients. Patients with syndesmophyte had higher BMI than those without syndesmophyte (24.2 ± 3.6 vs. 22.9 ± 3.3, p < 0.001). Multivariate logistic regression analysis showed that increased BMI was closely related with the presence of syndesmophyte (OR = 1.086, 95% CI 1.031-1.143, p = 0.002) Conclusions: Our results imply that increased BMI is significantly associated with the presence of syndesmophyte, but not with disease activity in axSpA.
OBJECTIVE: We investigated whether body mass index (BMI) is associated with parameters of disease activity and clinical manifestations in axial spondyloarthritis (axSpA). METHODS: Demographic, clinical, and radiological features and disease activity indexes from 789 axSpA patients (619 males and 170 females) were obtained from the Korean College of Rheumatology BIOlogics (KOBIO) registry. BMI (kg/m2) was classified into normal (BMI <23.0), overweight (23.0 ≤ BMI <25.0), and obese (BMI ≥25.0). Disease activity indexes included Bath ankylosing spondylitis disease activity index (BASDAI), erythrocyte sediment rate (ESR), C-reactive protein (CRP), and ankylosing spondylitis disease activity score (ASDAS). RESULTS: The mean BMI in patients with axSpA was 23.3 ± 3.5. 50.2% of all patients were overweight or obese. Overweight/obesepatients had more syndesmophyte and less peripheral arthritis than those in normal BMI patients (p < 0.001 and p < 0.030, respectively). BMI was not associated with disease activity indexes in axSpA patients. Patients with syndesmophyte had higher BMI than those without syndesmophyte (24.2 ± 3.6 vs. 22.9 ± 3.3, p < 0.001). Multivariate logistic regression analysis showed that increased BMI was closely related with the presence of syndesmophyte (OR = 1.086, 95% CI 1.031-1.143, p = 0.002) Conclusions: Our results imply that increased BMI is significantly associated with the presence of syndesmophyte, but not with disease activity in axSpA.
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Keywords:
Body mass index; Disease activity; Spondyloarthritis; Syndesmophyte