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Literature DB >> 27918529

HSD2 neurons in the hindbrain drive sodium appetite.

Brooke C Jarvie¹, Richard D Palmiter^1,2.

Abstract

Sodium-depleted animals develop an appetite for aversive concentrations of sodium. Here we show that chemogenetic activation of aldosterone-sensitive neurons that express 11β-hydroxysteroid dehydrogenase type 2 (HSD2) in the nucleus of the solitary tract is sufficient to drive consumption of sodium-containing solutions in mice, independently of thirst or hunger. These HSD2-positive neurons are necessary for full expression of sodium appetite and have distinct downstream targets that are activated during sodium depletion.

Entities: Chemical Gene Species

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Year: 2016 PMID： 27918529 DOI： 10.1038/nn.4451

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

26 in total

1. Aldosterone-sensitive neurons in the rat central nervous system.

Authors: Joel C Geerling; Mitsuhiro Kawata; Arthur D Loewy
Journal: J Comp Neurol Date: 2006-01-20 Impact factor: 3.215

2. Aldosterone-sensitive neurons in the nucleus of the solitary: efferent projections.

Authors: Joel C Geerling; Arthur D Loewy
Journal: J Comp Neurol Date: 2006-09-20 Impact factor: 3.215

3. DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite.

Authors: Haley L Nation; Marvin Nicoleau; Brian J Kinsman; Kirsteen N Browning; Sean D Stocker
Journal: J Neurophysiol Date: 2016-03-30 Impact factor: 2.714

4. FoxP2 expression defines dorsolateral pontine neurons activated by sodium deprivation.

Authors: Joel C Geerling; Matthew K Stein; Rebecca L Miller; Jung-Won Shin; Paul A Gray; Arthur D Loewy
Journal: Brain Res Date: 2010-11-23 Impact factor: 3.252

5. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus.

Authors: Joel C Geerling; Minjee Kim; Carrie E Mahoney; Stephen B G Abbott; Lindsay J Agostinelli; Alastair S Garfield; Michael J Krashes; Bradford B Lowell; Thomas E Scammell
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2015-10-21 Impact factor: 3.619

Review 6. Neuroendocrine control of body fluid metabolism.

Authors: José Antunes-Rodrigues; Margaret de Castro; Lucila L K Elias; Marcelo M Valença; Samuel M McCann
Journal: Physiol Rev Date: 2004-01 Impact factor: 37.312

Review 7. 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.

Authors: Karen Chapman; Megan Holmes; Jonathan Seckl
Journal: Physiol Rev Date: 2013-07 Impact factor: 37.312

8. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.

Authors: Yexica Aponte; Deniz Atasoy; Scott M Sternson
Journal: Nat Neurosci Date: 2010-01-05 Impact factor: 24.884

9. Thirst driving and suppressing signals encoded by distinct neural populations in the brain.

Authors: Yuki Oka; Mingyu Ye; Charles S Zuker
Journal: Nature Date: 2015-01-26 Impact factor: 49.962

10. Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.

Authors: Louise C Evans; Jessica R Ivy; Caitlin Wyrwoll; Julie A McNairn; Robert I Menzies; Thorbjørn H Christensen; Emad A S Al-Dujaili; Christopher J Kenyon; John J Mullins; Jonathan R Seckl; Megan C Holmes; Matthew A Bailey
Journal: Circulation Date: 2016-03-07 Impact factor: 29.690

29 in total

Review 1. Neural circuits underlying thirst and fluid homeostasis.

Authors: Christopher A Zimmerman; David E Leib; Zachary A Knight
Journal: Nat Rev Neurosci Date: 2017-06-22 Impact factor: 34.870

2. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.

Authors: Jon M Resch; Henning Fenselau; Joseph C Madara; Chen Wu; John N Campbell; Anna Lyubetskaya; Brian A Dawes; Linus T Tsai; Monica M Li; Yoav Livneh; Qingen Ke; Peter M Kang; Géza Fejes-Tóth; Anikó Náray-Fejes-Tóth; Joel C Geerling; Bradford B Lowell
Journal: Neuron Date: 2017-09-27 Impact factor: 17.173

HSD2 neurons in the hindbrain drive sodium appetite.

1. Aldosterone-sensitive neurons in the rat central nervous system.

2. Aldosterone-sensitive neurons in the nucleus of the solitary: efferent projections.

3. DREADD-induced activation of subfornical organ neurons stimulates thirst and salt appetite.

4. FoxP2 expression defines dorsolateral pontine neurons activated by sodium deprivation.

5. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus.

Review 6. Neuroendocrine control of body fluid metabolism.

Review 7. 11β-hydroxysteroid dehydrogenases: intracellular gate-keepers of tissue glucocorticoid action.

8. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training.

9. Thirst driving and suppressing signals encoded by distinct neural populations in the brain.

10. Conditional Deletion of Hsd11b2 in the Brain Causes Salt Appetite and Hypertension.

Review 1. Neural circuits underlying thirst and fluid homeostasis.

2. Aldosterone-Sensing Neurons in the NTS Exhibit State-Dependent Pacemaker Activity and Drive Sodium Appetite via Synergy with Angiotensin II Signaling.

3. Pass the salt: the central control of sodium intake.

Review 4. Neural Control and Modulation of Thirst, Sodium Appetite, and Hunger.

5. Barrington's nucleus: Neuroanatomic landscape of the mouse "pontine micturition center".

Review 6. Peripheral and Central Nutrient Sensing Underlying Appetite Regulation.

7. Internal amino acid state modulates yeast taste neurons to support protein homeostasis in Drosophila.

8. Neuronal (pro)renin receptor regulates deoxycorticosterone-induced sodium intake.

9. Central afferents to the nucleus of the solitary tract in rats and mice.

10. Aldosterone-sensitive HSD2 neurons in mice.