Literature DB >> 27918113

Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment.

Yue Chen1,2, Ming Xu1, Jie Zhang1, Juan Ma1, Ming Gao1, Zhihong Zhang2, Yong Xu2, Sijin Liu1.   

Abstract

Sublethal exposure of engineered nanomaterials (ENMs) induces the alteration of various cellular processes due to DNA methylation changes. DNA methylation variations represent a more sensitive fingerprint analysis of the direct and indirect effects that may be overlooked by traditional toxicity assays, and an understanding of the structure-activity relationship of DNA methylation upon ENMs would open a new path for their safer design.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  DNA methylation; adverse outcomes; engineered nanomaterials; nanosafety

Year:  2016        PMID： 27918113     DOI： 10.1002/adma.201604580

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


  7 in total

Review 1.  Nanosafety: An Evolving Concept to Bring the Safest Possible Nanomaterials to Society and Environment.

Authors:  Filipa Lebre; Nivedita Chatterjee; Samantha Costa; Eli Fernández-de-Gortari; Carla Lopes; João Meneses; Luís Ortiz; Ana R Ribeiro; Vânia Vilas-Boas; Ernesto Alfaro-Moreno
Journal:  Nanomaterials (Basel)       Date:  2022-05-25       Impact factor: 5.719

2.  Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.

Authors:  Ming Gao; Minjun Chen; Changying Li; Ming Xu; Yun Liu; Min Cong; Nan Sang; Sijin Liu
Journal:  Cell Discov       Date:  2018-01-30       Impact factor: 10.849

3.  MicroRNA Response and Toxicity of Potential Pathways in Human Colon Cancer Cells Exposed to Titanium Dioxide Nanoparticles.

Authors:  Wen Li; Ming Xi Jia; Jing Deng; Jian Hui Wang; Zavuga Zuberi; Sheng Yang; Jie Ba; Zhu Chen
Journal:  Cancers (Basel)       Date:  2020-05-14       Impact factor: 6.639

4.  RNA m6A Alterations Induced by Biomineralization Nanoparticles: A Proof-of-Concept Study of Epitranscriptomics for Nanotoxicity Evaluation.

Authors:  Jinbin Pan; Jiaojiao Wang; Kun Fang; Wenjing Hou; Bing Li; Jie Zhao; Xinlong Ma
Journal:  Nanoscale Res Lett       Date:  2022-02-05       Impact factor: 5.418

5.  Intracellular Exposure Dose-Associated Susceptibility of Steatotic Hepatocytes to Metallic Nanoparticles.

Authors:  Xiaoli Zhang; Yongyi Wei; Chengjun Li; Weiyu Wang; Rui Zhang; Jianbo Jia; Bing Yan
Journal:  Int J Mol Sci       Date:  2021-11-23       Impact factor: 5.923

6.  Early Epigenetic Responses in the Genomic DNA Methylation Fingerprints in Cells in Response to Sublethal Exposure of Silver Nanoparticles.

Authors:  Yue Chen; Fei Sheng; Xingyu Wang; Zhihong Zhang; Shiyong Qi; Liqun Chen
Journal:  Front Bioeng Biotechnol       Date:  2022-06-16

7.  Anticancer Effects of Zinc Oxide Nanoparticles Through Altering the Methylation Status of Histone on Bladder Cancer Cells.

Authors:  Tianke Zhang; E Du; Yan Liu; Jun Cheng; Zhihong Zhang; Yong Xu; Shiyong Qi; Yue Chen
Journal:  Int J Nanomedicine       Date:  2020-03-05
  7 in total

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