U C Megwalu1, A T Saini2. 1. Department of Otolaryngology - Head and Neck Surgery,Stanford University School of Medicine,California,USA. 2. Department of Otolaryngology - Head and Neck Surgery,Icahn School of Medicine at Mount Sinai,New York,USA.
Abstract
OBJECTIVE: To evaluate the impact of race on survival in patients with papillary thyroid microcarcinoma. METHODS: The study cohort included 17 668 patients diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute. RESULTS: Black patients had lower overall survival than other racial groups (p < 0.001). Black patients had significantly worse overall survival (hazard ratio = 2.59) after adjusting for sex, marital status, age, year of diagnosis, multifocal disease and type of surgery. A subset analysis of Black patients revealed no significant difference in overall survival for total thyroidectomy versus lobectomy (p = 0.15). CONCLUSION: Black race is a negative prognostic factor in thyroid cancer, which cannot be explained by advanced disease stage. Further research on mechanisms by which race affects survival is needed to reveal areas of opportunity for interventions aimed at reducing health disparities in cancer care.
OBJECTIVE: To evaluate the impact of race on survival in patients with papillary thyroid microcarcinoma. METHODS: The study cohort included 17 668 patients diagnosed with papillary thyroid microcarcinoma between 1988 and 2009, identified in the Surveillance, Epidemiology, and End Results 18 database of the National Cancer Institute. RESULTS: Black patients had lower overall survival than other racial groups (p < 0.001). Black patients had significantly worse overall survival (hazard ratio = 2.59) after adjusting for sex, marital status, age, year of diagnosis, multifocal disease and type of surgery. A subset analysis of Black patients revealed no significant difference in overall survival for total thyroidectomy versus lobectomy (p = 0.15). CONCLUSION: Black race is a negative prognostic factor in thyroid cancer, which cannot be explained by advanced disease stage. Further research on mechanisms by which race affects survival is needed to reveal areas of opportunity for interventions aimed at reducing health disparities in cancer care.
Entities:
Keywords:
Health Status Disparities; Minority Health; SEER Program; Thyroid Neoplasms
Authors: Zachary Hurst; Sandya Liyanarachchi; Huiling He; Pamela Brock; Jennifer Sipos; Fadi Nabhan; Electron Kebebew; Patience Green; Gilbert J Cote; Steven Sherman; Christopher J Walker; Yi Seok Chang; Shuai Xue; Brynn Hollingsworth; Wei Li; Luke Genutis; Eric Menq; Albert de la Chapelle; Sissy M Jhiang Journal: Thyroid Date: 2019-02-13 Impact factor: 6.568
Authors: Ammar Asban; Sebastian K Chung; Rongbing Xie; Brenessa M Lindeman; Courtney J Balentine; James K Kirklin; Herbert Chen Journal: Clin Med Insights Endocrinol Diabetes Date: 2019-09-25