Literature DB >> 27917697

Current and future biomarkers in the treatment of colorectal cancer.

Pieter-Jan Cuyle1,2, Hans Prenen2.   

Abstract

Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. CRC develops as a consequence of genomic instability, characterized by various genetic and epigenetic alterations. Its molecular heterogeneity explains the large variability in patient prognosis and treatment response, emphasizing the need for development of accurate prognostic and predictive biomarkers. This article delineates the different pathways of colorectal carcinogenesis and its molecular subtype classification. With this review, we aim to provide a comprehensive overview of the current and future biomarkers guiding clinical decision-making and CRC treatment.

Entities:  

Keywords:  BRAF; CDX2; Colorectal cancer; DNA mismatch repair; EGFR; HER2; Liquid biopsy; MSI; Molecular subtypes; Personalized medicine; Predictive markers; Prognostic markers; RAS; Targeted therapy; VEGF

Mesh：

Substances：

Year:  2016        PMID： 27917697     DOI： 10.1080/17843286.2016.1262996

Source DB:  PubMed          Journal:  Acta Clin Belg        ISSN： 1784-3286            Impact factor:   1.264


  10 in total

1.  Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer.

Authors:  Yuchen Guo; Monica Gabola; Rossano Lattanzio; Conception Paul; Valérie Pinet; Ruizhi Tang; Hulya Turali; Julie Bremond; Ciro Longobardi; Chloé Maurizy; Quentin Da Costa; Pascal Finetti; Florence Boissière-Michot; Benjamin Rivière; Céline Lemmers; Séverine Garnier; François Bertucci; Inti Zlobec; Karim Chebli; Jamal Tazi; Rania Azar; Jean-Marie Blanchard; Peter Sicinski; Emilie Mamessier; Bénédicte Lemmers; Michael Hahne
Journal:  J Clin Invest       Date:  2021-02-15       Impact factor: 14.808

2.  Polymorphisms of xenobiotic-metabolizing and transporter genes, and the risk of gastric and colorectal cancer in an admixed population from the Brazilian Amazon.

Authors:  Amanda Nazaré Cohen Lima de Castro; Marianne Rodrigues Fernandes; Darlen Cardoso de Carvalho; Tatiane Piedade de Souza; Juliana Carla Gomes Rodrigues; Roberta Borges Andrade; Antonio Andre Conde Modesto; Sidney Santos; Paulo Pimentel Assumpção; Ney Pereira Carneiro Dos Santos
Journal:  Am J Transl Res       Date:  2020-10-15       Impact factor: 4.060

3.  Angiodrastic Chemokines in Colorectal Cancer: Clinicopathological Correlations.

Authors:  George Emmanouil; George Ayiomamitis; Adamantia Zizi-Sermpetzoglou; Maria Tzardi; Andrew Moursellas; Argyro Voumvouraki; Elias Kouroumalis
Journal:  Anal Cell Pathol (Amst)       Date:  2018-04-16       Impact factor: 2.916

4.  High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway.

Authors:  Liguo Liu; Xuebing Yan; Dapeng Wu; Yi Yang; Mengcheng Li; Yang Su; Wenchao Yang; Zezhi Shan; Yuping Gao; Zhiming Jin
Journal:  J Exp Clin Cancer Res       Date:  2018-07-31

5.  High expression of TFEB is associated with aggressive clinical features in colorectal cancer.

Authors:  Jing Liang; Xinfeng Jia; Kun Wang; Niankun Zhao
Journal:  Onco Targets Ther       Date:  2018-11-13       Impact factor: 4.147

6.  Identification of a 13-gene-based classifier as a potential biomarker to predict the effects of fluorouracil-based chemotherapy in colorectal cancer.

Authors:  Zuhuan Gan; Qiyuan Zou; Yan Lin; Zihai Xu; Zhong Huang; Zhichao Chen; Yufeng Lv
Journal:  Oncol Lett       Date:  2019-03-19       Impact factor: 2.967

7.  Hsa_circ_0045932 regulates the progression of colorectal cancer by regulating HK2 through sponging miR-873-5p.

Authors:  Feng Hong; Zhihua Deng; Ruxiu Tie; Senlin Yang
Journal:  J Clin Lab Anal       Date:  2022-08-10       Impact factor: 3.124

8.  Image-Based Network Analysis of DNp73 Expression by Immunohistochemistry in Rectal Cancer Patients.

Authors:  Tuan D Pham; Chuanwen Fan; Daniella Pfeifer; Hong Zhang; Xiao-Feng Sun
Journal:  Front Physiol       Date:  2020-01-08       Impact factor: 4.566

Review 9.  DNA methylation markers detected in blood, stool, urine, and tissue in colorectal cancer: a systematic review of paired samples.

Authors:  Eivor Alette Laugsand; Siv Sellæg Brenne; Frank Skorpen
Journal:  Int J Colorectal Dis       Date:  2020-10-06       Impact factor: 2.796

10.  Expression and prognostic significance of CBX2 in colorectal cancer: database mining for CBX family members in malignancies and vitro analyses.

Authors:  He Zhou; Yong Xiong; Yongfu Xiong; Zuoliang Liu; Songlin Hou; Tong Zhou
Journal:  Cancer Cell Int       Date:  2021-07-28       Impact factor: 5.722
  10 in total

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