Chuanyuan Tao1, Xin Hu1, Jiajing Wang2, Junpeng Ma1, Hao Li1, Chao You1. 1. Stroke Clinical Research Unit, Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR China. 2. Department of Critical Care Medicine, Neurosurgical Intensive Care Unit, West China Hospital, Sichuan University, Chengdu 610041, PR China.
Abstract
AIM: Inflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte count and neutrophil to lymphocyte ratio (NLR) for 90-day outcome after ICH. PATIENTS & METHODS: A total of 336 patients with spontaneous ICH were retrospectively investigated. Clinical outcome was assessed by modified Rankin Scale at 90 days. RESULTS: Multivariate analysis showed that higher AWC, ANC, NLR were independently associated with mortality and worse outcome. Moreover, NLR showed a higher predictive ability in mortality than in poor outcome in receiver operating characteristic analysis. Linear regression analyses revealed admission Glasgow Coma Scale score and ICH volume were mostly correlated with these indices. CONCLUSION: Elevated levels of AWC, ANC and NLR were independently related to poor 90-day outcome after ICH. NLR may be a novel inflammatory biomarker following ICH.
AIM: Inflammation plays a role in secondary brain injury after intracerebral hemorrhage (ICH). We aimed to determine the prognostic significance of admission white blood cell (AWC), neutrophil count (ANC), lymphocyte count, monocyte count and neutrophil to lymphocyte ratio (NLR) for 90-day outcome after ICH. PATIENTS & METHODS: A total of 336 patients with spontaneous ICH were retrospectively investigated. Clinical outcome was assessed by modified Rankin Scale at 90 days. RESULTS: Multivariate analysis showed that higher AWC, ANC, NLR were independently associated with mortality and worse outcome. Moreover, NLR showed a higher predictive ability in mortality than in poor outcome in receiver operating characteristic analysis. Linear regression analyses revealed admission Glasgow Coma Scale score and ICH volume were mostly correlated with these indices. CONCLUSION: Elevated levels of AWC, ANC and NLR were independently related to poor 90-day outcome after ICH. NLR may be a novel inflammatory biomarker following ICH.
Authors: Artur Nóbrega Lima Rodrigues de Morais; Victor Matheus Ribeiro Baylão; Tamires Martins Silva; Alexandra Gomes Dos Santos; Mayara Azevedo; Adilson J M de Oliveira Journal: Neurosurg Rev Date: 2021-02-15 Impact factor: 3.042
Authors: Fan Zhang; Yanming Ren; Yan Shi; Wei Fu; Chuanyuan Tao; Xi Li; Mu Yang; Chao You; Tao Xin Journal: Medicine (Baltimore) Date: 2019-06 Impact factor: 1.817