Literature DB >> 27917001

MULTICOMPONENT REACTIONS IN ALKALOID-BASED DRUG DISCOVERY.

I V Magedov1, A Kornienko1.   

Abstract

Multicomponent reactions are emerging as a powerful tool in alkaloid-based drug discovery. This Highlight describes several recent (all published in 2011) examples of the employment of multicomponent reactions for the synthesis of biologically active alkaloids and their medicinally relevant analogues.

Entities:  

Keywords:  alkaloid; cyanocycline A; drug discovery; luotonin; multicomponent reactions; rigidin; tubulysin

Year:  2012        PMID： 27917001      PMCID： PMC5130108          DOI： 10.1007/s10593-012-0965-7

Source DB:  PubMed          Journal:  Chem Heterocycl Compd (N Y)        ISSN： 0009-3122            Impact factor:   1.277


  6 in total

Review 1.  Recent developments in isocyanide based multicomponent reactions in applied chemistry.

Authors:  Alexander Dömling
Journal:  Chem Rev       Date:  2006-01       Impact factor: 60.622

Review 2.  Natural product synthesis using multicomponent reaction strategies.

Authors:  Barry B Touré; Dennis G Hall
Journal:  Chem Rev       Date:  2009-09       Impact factor: 60.622

3.  Asymmetric [C + NC + CC] coupling entry to the naphthyridinomycin natural product family: formal total synthesis of cyanocycline A and bioxalomycin β2.

Authors:  Philip Garner; H Ümit Kaniskan; Charles M Keyari; Laksiri Weerasinghe
Journal:  J Org Chem       Date:  2011-05-31       Impact factor: 4.354

4.  One-pot synthesis of luotonin A and its analogues.

Authors:  Ming-Chung Tseng; Yu-Wan Chu; Hsiang-Ping Tsai; Chun-Mao Lin; Jaulang Hwang; Yen-Ho Chu
Journal:  Org Lett       Date:  2011-01-26       Impact factor: 6.005

5.  One-pot multicomponent synthesis of diversely substituted 2-aminopyrroles. A short general synthesis of rigidins A, B, C, and D.

Authors:  Liliya V Frolova; Nikolai M Evdokimov; Kathryn Hayden; Indranil Malik; Snezna Rogelj; Alexander Kornienko; Igor V Magedov
Journal:  Org Lett       Date:  2011-01-26       Impact factor: 6.005

6.  The multiple multicomponent approach to natural product mimics: tubugis, N-substituted anticancer peptides with picomolar activity.

Authors:  Orlando Pando; Sebastian Stark; Annika Denkert; Andrea Porzel; Rainer Preusentanz; Ludger A Wessjohann
Journal:  J Am Chem Soc       Date:  2011-04-29       Impact factor: 15.419
  6 in total
  3 in total

1.  Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.

Authors:  Liliya V Frolova; Igor V Magedov; Anntherese E Romero; Menuka Karki; Isaiah Otero; Kathryn Hayden; Nikolai M Evdokimov; Laetitia Moreno Y Banuls; Shiva K Rastogi; W Ross Smith; Shi-Long Lu; Robert Kiss; Charles B Shuster; Ernest Hamel; Tania Betancourt; Snezna Rogelj; Alexander Kornienko
Journal:  J Med Chem       Date:  2013-08-23       Impact factor: 7.446

2.  Catalyst free, C-3 functionalization of imidazo[1,2-a]pyridines to rapidly access new chemical space for drug discovery efforts.

Authors:  Naresh Gunaganti; Anupreet Kharbanda; Naga Rajiv Lakkaniga; Lingtian Zhang; Rose Cooper; Hong-Yu Li; Brendan Frett
Journal:  Chem Commun (Camb)       Date:  2018-11-15       Impact factor: 6.222

3.  Mo@GAA-Fe3O4 MNPs: a highly efficient and environmentally friendly heterogeneous magnetic nanocatalyst for the synthesis of polyhydroquinoline derivatives.

Authors:  Mehraneh Aghaei-Hashjin; Asieh Yahyazadeh; Esmayeel Abbaspour-Gilandeh
Journal:  RSC Adv       Date:  2021-03-11       Impact factor: 3.361
  3 in total

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