Literature DB >> 27916546

New direct-acting antivirals for patients with chronic HCV infection: can we monitor treatment using an HCV core antigen assay?

R Alonso1, F Pérez-García2, D Ampuero3, E Reigadas4, E Bouza5.   

Abstract

We evaluated the diagnostic usefulness of an HCV core antigen (HCV-Ag) assay in HCV-infected patients undergoing treatment with direct-acting antivirals. We analyzed 103 samples from 28 patients. Compared with RT-PCR, sensitivity was 96.2% and specificity was 100%. The correlation between techniques was excellent (Pearson coefficient: 0.871). HCV-Ag proved to be useful in patients with sustained viral response and in patients who experienced treatment failures.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Automatized systems; Correlation; Direct-acting antiviral agents; HCV core antigen; Hepatitis C virus

Mesh：

Substances：

Year:  2016        PMID： 27916546     DOI： 10.1016/j.diagmicrobio.2016.11.010

Source DB:  PubMed          Journal:  Diagn Microbiol Infect Dis        ISSN： 0732-8893            Impact factor:   2.803


  5 in total

1.  Multicenter Evaluation of the Cepheid Xpert Hepatitis C Virus Viral Load Assay.

Authors:  M P McHugh; A H B Wu; S Chevaliez; J M Pawlotsky; M Hallin; K E Templeton
Journal:  J Clin Microbiol       Date:  2017-03-08       Impact factor: 5.948

Review 2.  HCV core antigen plays an important role in the fight against HCV as an alternative to HCV-RNA detection.

Authors:  Yuhan Wang; Wang Jie; Jiang Ling; Huang Yuanshuai
Journal:  J Clin Lab Anal       Date:  2021-03-31       Impact factor: 2.352

3.  HCV core antigen is an alternative marker to HCV RNA for evaluating active HCV infection: implications for improved diagnostic option in an era of affordable DAAs.

Authors:  Rujipat Wasitthankasem; Preeyaporn Vichaiwattana; Chompoonut Auphimai; Nipaporn Siripon; Sirapa Klinfueng; Pisit Tangkijvanich; Sompong Vongpunsawad; Yong Poovorawan
Journal:  PeerJ       Date:  2017-11-06       Impact factor: 2.984

4.  Performance of HCV Antigen Testing for the Diagnosis and Monitoring of Antiviral Treatment: A Systematic Review and Meta-Analysis.

Authors:  Geane Lopes Flores; Jurema Corrêa Mota; Larissa Tropiano da Silva Andrade; Renata Serrano Lopes; Francisco Inácio Bastos; Livia Melo Villar
Journal:  Biomed Res Int       Date:  2022-01-04       Impact factor: 3.411

5.  Study of Hepatitis C Virus Detection Assays.

Authors:  Mithaq Sabeeh Khudur Al-Nassary; Batool Mutar Mahdi
Journal:  Ann Med Surg (Lond)       Date:  2018-10-06
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.