Literature DB >> 27916437

Animal testing is still the best way to find new treatments for patients.

Silvio Garattini1, Giuliano Grignaschi2.   

Abstract

Experimental research proceeds by hypotheses formulated on the basis of previous or new knowledge and then tested. If they are accepted, they serve as the basis for further hypotheses, and if they are rejected new hypotheses can be developed. In other words, when we are at the frontiers of knowledge the path is forged by "trial and error". When a trial shows a hypothesis is wrong, this is a step toward making fewer errors. This process also applies to drug development. There is no magic formula at present to predict - at the pre-clinical level - the therapeutic value of a drug for people with a disease. However, pre-clinical studies are needed in order to formulate hypotheses that justify clinical trials. Without these preliminary studies in vitro and in vivo in selected animal species it would be unethical to test still unproven chemicals in humans.
Copyright © 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Animal testing; Experimental research

Mesh:

Year:  2016        PMID: 27916437     DOI: 10.1016/j.ejim.2016.11.013

Source DB:  PubMed          Journal:  Eur J Intern Med        ISSN: 0953-6205            Impact factor:   4.487


  11 in total

1.  The 3Rs Principle in Animal Experimentation: A Legal Review of the State of the Art in Europe and the Case in Italy.

Authors:  Enrico Maestri
Journal:  BioTech (Basel)       Date:  2021-05-20

2.  Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer.

Authors:  Nancy Gavert; Yaara Zwang; Roi Weiser; Orli Greenberg; Sharon Halperin; Oded Jacobi; Giuseppe Mallel; Oded Sandler; Adi Jacob Berger; Erez Stossel; Daniil Rotin; Albert Grinshpun; Iris Kamer; Jair Bar; Guy Pines; Daniel Saidian; Ilan Bar; Shay Golan; Eli Rosenbaum; Andrei Nadu; Eytan Ben-Ami; Rony Weitzen; Hovav Nechushtan; Talia Golan; Baruch Brenner; Aviram Nissan; Ofer Margalit; Dov Hershkovitz; Guy Lahat; Ravid Straussman
Journal:  Nat Cancer       Date:  2022-02-10

Review 3.  Are the Lives of Animals Well-spent in Laboratory Science Research? A Study of Orthopaedic Animal Studies in Turkey.

Authors:  Alper Öztürk; Önder Ersan
Journal:  Clin Orthop Relat Res       Date:  2020-09       Impact factor: 4.755

4.  Si-Wei-Qing-Gan-Tang Improves Non-Alcoholic Steatohepatitis by Modulating the Nuclear Factor-κB Signal Pathway and Autophagy in Methionine and Choline Deficient Diet-Fed Rats.

Authors:  Lingyun Xiao; Shu Liang; Lanlan Ge; Shuling Qiu; Haoqiang Wan; Shipin Wu; Jia Fei; Shusong Peng; Xiaobin Zeng
Journal:  Front Pharmacol       Date:  2020-05-01       Impact factor: 5.810

5.  Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells.

Authors:  Simon Lagies; Manuel Schlimpert; Simon Neumann; Astrid Wäldin; Bernd Kammerer; Christoph Borner; Lukas Peintner
Journal:  Commun Biol       Date:  2020-05-19

6.  Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate.

Authors:  Milvija Plazibat; Ana Katušić Bojanac; Marta Himerleich Perić; Ozren Gamulin; Mario Rašić; Vedran Radonić; Marko Škrabić; Maria Krajačić; Jure Krasić; Nino Sinčić; Gordana Jurić-Lekić; Maja Balarin; Floriana Bulić-Jakuš
Journal:  FEBS J       Date:  2020-02-28       Impact factor: 5.542

7.  Density Functional Theory in the Prediction of Mutagenicity: A Perspective.

Authors:  Piers A Townsend; Matthew N Grayson
Journal:  Chem Res Toxicol       Date:  2020-08-07       Impact factor: 3.739

8.  Hepatic lipid profile in mice fed a choline-deficient, low-methionine diet resembles human non-alcoholic fatty liver disease.

Authors:  Elisabeth M Haberl; Rebekka Pohl; Lisa Rein-Fischboeck; Marcus Höring; Sabrina Krautbauer; Gerhard Liebisch; Christa Buechler
Journal:  Lipids Health Dis       Date:  2020-12-09       Impact factor: 3.876

9.  Accumulation of cholesterol, triglycerides and ceramides in hepatocellular carcinomas of diethylnitrosamine injected mice.

Authors:  Elisabeth M Haberl; Rebekka Pohl; Lisa Rein-Fischboeck; Marcus Höring; Sabrina Krautbauer; Gerhard Liebisch; Christa Buechler
Journal:  Lipids Health Dis       Date:  2021-10-10       Impact factor: 3.876

10.  The Value of Mouse Models of Rare Diseases: A Spanish Experience.

Authors:  Silvia Murillo-Cuesta; Rafael Artuch; Fernando Asensio; Pedro de la Villa; Mara Dierssen; Jose Antonio Enríquez; Cristina Fillat; Stéphane Fourcade; Borja Ibáñez; Lluis Montoliu; Eduardo Oliver; Aurora Pujol; Eduardo Salido; Mario Vallejo; Isabel Varela-Nieto
Journal:  Front Genet       Date:  2020-10-14       Impact factor: 4.599

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