Daniela Schmid1, Gundula Behrens2, Charles E Matthews3, Michael F Leitzmann2. 1. Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. Electronic address: daniela.schmid@klinik.uni-regensburg.de. 2. Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. 3. Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute, Bethesda, MD.
Abstract
OBJECTIVE: To determine whether moderate to vigorous physical activity is associated with a decreased risk of colon cancer in diabetic patients. PATIENTS AND METHODS: We evaluated the association between physical activity and colon cancer in 25,753 patients with a self-reported history of diabetes and in 274,965 nondiabetic individuals from the National Institutes of Health-AARP Diet and Health Study who were aged 50 to 71 years in 1995-1996. Moderate to vigorous physical activity was assessed at baseline using a self-administered questionnaire. Follow-up for colon cancer incidence extended to December 31, 2011. RESULTS: During 13.0 years of follow-up, 480 diabetic patients and 4151 nondiabetic individuals had development of colon cancer. Among diabetic patients, compared with never/rarely engaging in physical activity, more than 7 h/wk of physical activity exhibited a reduced risk of colon cancer in the age- and sex-adjusted model (hazard ratio [HR], 0.74; 95% CI, 0.56-0.996; P=.16 for trend). This association was attenuated and no longer statistically significant after additional control for other covariates (HR, 0.78; 95% CI, 0.58-1.05; P=.29 for trend). By comparison, physical activity was inversely related to colon cancer risk in nondiabetic individuals (multivariate-adjusted HR, 0.81; 95% CI, 0.73-0.89; P<.001 for trend). CONCLUSION: In this investigation of the relationship between physical activity and colon cancer in diabetic patients, we found a statistically significant inverse relationship in the age- and sex-adjusted model, which was no longer statistically significant in the multivariate-adjusted model. A reduced risk was noted among nondiabetic individuals, irrespective of other covariates. Future studies with a larger number of participants are required to explore whether physical activity beneficially affects colon cancer risk among diabetic patients. Copyright Â
OBJECTIVE: To determine whether moderate to vigorous physical activity is associated with a decreased risk of colon cancer in diabeticpatients. PATIENTS AND METHODS: We evaluated the association between physical activity and colon cancer in 25,753 patients with a self-reported history of diabetes and in 274,965 nondiabetic individuals from the National Institutes of Health-AARP Diet and Health Study who were aged 50 to 71 years in 1995-1996. Moderate to vigorous physical activity was assessed at baseline using a self-administered questionnaire. Follow-up for colon cancer incidence extended to December 31, 2011. RESULTS: During 13.0 years of follow-up, 480 diabeticpatients and 4151 nondiabetic individuals had development of colon cancer. Among diabeticpatients, compared with never/rarely engaging in physical activity, more than 7 h/wk of physical activity exhibited a reduced risk of colon cancer in the age- and sex-adjusted model (hazard ratio [HR], 0.74; 95% CI, 0.56-0.996; P=.16 for trend). This association was attenuated and no longer statistically significant after additional control for other covariates (HR, 0.78; 95% CI, 0.58-1.05; P=.29 for trend). By comparison, physical activity was inversely related to colon cancer risk in nondiabetic individuals (multivariate-adjusted HR, 0.81; 95% CI, 0.73-0.89; P<.001 for trend). CONCLUSION: In this investigation of the relationship between physical activity and colon cancer in diabeticpatients, we found a statistically significant inverse relationship in the age- and sex-adjusted model, which was no longer statistically significant in the multivariate-adjusted model. A reduced risk was noted among nondiabetic individuals, irrespective of other covariates. Future studies with a larger number of participants are required to explore whether physical activity beneficially affects colon cancer risk among diabeticpatients. Copyright Â
Authors: Anne McTiernan; Christine M Friedenreich; Peter T Katzmarzyk; Kenneth E Powell; Richard Macko; David Buchner; Linda S Pescatello; Bonny Bloodgood; Bethany Tennant; Alison Vaux-Bjerke; Stephanie M George; Richard P Troiano; Katrina L Piercy Journal: Med Sci Sports Exerc Date: 2019-06 Impact factor: 5.411
Authors: Eileen Shaw; Megan S Farris; Chelsea R Stone; Jeroen W G Derksen; Rhys Johnson; Robert J Hilsden; Christine M Friedenreich; Darren R Brenner Journal: BMC Cancer Date: 2018-01-11 Impact factor: 4.430