Sibelnur Avcil1, Pınar Uysal2, Mucahit Avcil3, Murat Alışık4, Cemile Biçer4. 1. Adnan Menderes University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Aydın, Turkey. Electronic address: snuravcil@yahoo.com.tr. 2. Adnan Menderes University, Faculty of Medicine, Department of Pediatric Allergy and Immunology, Aydın, Turkey. 3. Adnan Menderes University, Faculty of Medicine, Department of Emergency Medicine, Aydın, Turkey. 4. Yıldırım Beyazıd University, Faculty of Medicine, Department of Clinical Biochemistry, Ankara, Turkey.
Abstract
BACKGROUND: The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADHD) children for the first time in literature. METHODS: Ninety children with ADHD diagnosed according to DSM-V and as control group, 65 healthy children were included to the study. Native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol were compared between the groups. RESULTS: Total and native thiol levels were significantly higher whereas the disulfide/native thiol ratios were significantly lower in children with ADHD. ADHD combined type appeared to have higher disulfide, disulfide/native thiol and disulfide/total thiol ratios compared to other subtypes. Disulfide levels of the males with ADHD were significantly higher than those of the females with ADHD. CONCLUSION: This study suggests that thiol/disulfide homeostasis is abnormal in children with ADHD. It may be used as a novel OS marker in ADHD children because it is easy, practical, fully automated and relatively inexpensive.
BACKGROUND: The aim of this study was to evaluate a novel oxidative stress marker (thiol/disulfide homeostasis) in attention deficit hyperactivity disorder (ADHD) children for the first time in literature. METHODS: Ninety children with ADHD diagnosed according to DSM-V and as control group, 65 healthy children were included to the study. Native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol were compared between the groups. RESULTS: Total and native thiol levels were significantly higher whereas the disulfide/native thiol ratios were significantly lower in children with ADHD. ADHD combined type appeared to have higher disulfide, disulfide/native thiol and disulfide/total thiol ratios compared to other subtypes. Disulfide levels of the males with ADHD were significantly higher than those of the females with ADHD. CONCLUSION: This study suggests that thiol/disulfide homeostasis is abnormal in children with ADHD. It may be used as a novel OS marker in ADHDchildren because it is easy, practical, fully automated and relatively inexpensive.
Authors: Hamza Ayaydın; Fethiye Kılıçaslan; İsmail Koyuncu; Hakim Çelik; Mustafa Çalık; Ahmet Güzelçiçek; Adnan Kirmit Journal: J Mol Neurosci Date: 2021-01-12 Impact factor: 3.444