In vitro activity of lomefloxacin (SC 47111 or NY-198), a new quinolone antimicrobial, against clinical isolates of common pathogens.

The lomefloxacin antibacterial activity was assessed against 442 clinical isolates of common bacterial pathogens and compared to the previously studied activity of ciprofloxacin, imipenem, norfloxacin, and other commonly used antibacterials. Lomefloxacin showed activity against the species of Enterobacteriaceae tested at a concentration equal to or below that of the most commonly used agents. Activity was lower against Pseudomonas species as well as most Gram-positive isolates tested with the exception of Staphylococcus aureus. Streptococcal strains were least susceptible. The results of this study support previous reports of excellent antimicrobial activity for lomefloxacin, especially against Gram-negative organisms.