M Roux1, O Dassonville1, M Ettaiche2, G Poissonnet1, A Sudaka3, A Bozec4. 1. Institut universitaire de la face et du cou, 31, avenue de Valombrose, 06103 Nice, France. 2. Département de biostatistiques, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France. 3. Département d'anatomie pathologique, centre Antoine-Lacassagne, 33, avenue de Valombrose, 06189 Nice, France. 4. Institut universitaire de la face et du cou, 31, avenue de Valombrose, 06103 Nice, France. Electronic address: alexandre.bozec@nice.unicancer.fr.
Abstract
OBJECTIVE: To analyze postoperative course, oncologic and functional results and prognostic factors of transoral-transcervical oropharyngeal cancer surgery without mandibulotomy, associated to radial forearm free-flap reconstruction. MATERIAL AND METHODS: Retrospective analysis of computerized medical records of all patients who underwent this type of surgery in our institution between 2004 and 2014. Predictive factors of oncologic and functional results were investigated on univariate and multivariate analyses. RESULTS: Forty-four patients (37 male, 7 female; mean age, 62.3±9.3years) were included. Three-year overall, disease-specific and recurrence-free survival was 90%, 92% and 79%, respectively. Functional scores were satisfactory (normal or slight impairment) for feeding, speech and oral opening functions in 86%, 93% and 100% of cases, respectively. ASA score≥III had significantly negative impact on overall survival (P=0.005) and on feeding (P=0.01) and speech (P=0.01). CONCLUSION: Transoral-transcervical oropharyngeal cancer surgery without mandibulotomy provided excellent oncologic and functional outcomes; it is an advantageous alternative to the conventional conservative transmandibular oropharyngectomy.
OBJECTIVE: To analyze postoperative course, oncologic and functional results and prognostic factors of transoral-transcervical oropharyngeal cancer surgery without mandibulotomy, associated to radial forearm free-flap reconstruction. MATERIAL AND METHODS: Retrospective analysis of computerized medical records of all patients who underwent this type of surgery in our institution between 2004 and 2014. Predictive factors of oncologic and functional results were investigated on univariate and multivariate analyses. RESULTS: Forty-four patients (37 male, 7 female; mean age, 62.3±9.3years) were included. Three-year overall, disease-specific and recurrence-free survival was 90%, 92% and 79%, respectively. Functional scores were satisfactory (normal or slight impairment) for feeding, speech and oral opening functions in 86%, 93% and 100% of cases, respectively. ASA score≥III had significantly negative impact on overall survival (P=0.005) and on feeding (P=0.01) and speech (P=0.01). CONCLUSION: Transoral-transcervical oropharyngeal cancer surgery without mandibulotomy provided excellent oncologic and functional outcomes; it is an advantageous alternative to the conventional conservative transmandibular oropharyngectomy.
Authors: Philippe Gorphe; Anne Auperin; Jean-François Honart; Jean Ton Van; Sophie El Bedoui; François Bidault; Stéphane Temam; Frédéric Kolb; Quentin Qassemyar Journal: Laryngoscope Investig Otolaryngol Date: 2018-03-25