PURPOSE: Chest wall tumors in pediatric patients are rare. This study evaluates outcomes in pediatric patients who have undergone chest wall resections secondary to sarcomas. METHODS: A retrospective review was performed for patients <19years old who underwent chest wall resections for sarcoma 1999-2014 at the University of Texas MD Anderson Cancer Center. RESULTS: Of 44 patients, Ewing's sarcoma (n=18) and osteosarcoma (n=16) were most common. Other sarcomas included synovial sarcoma, chondrosarcoma, and rhabdomyosarcoma. Gore-Tex® or a Marlex™ mesh and methyl methacrylate sandwich was used in 22 patients, and 9 children did not require reconstruction. Twenty-four (54.5%) patients had normal activity, 3 (6.8%) had occasional discomfort, 2 (4.5%) had pain impairing function, 7 (15.9%) required medication or physical therapy for impairment, and 8 (18.2%) needed additional surgery. Five children (11.4%) developed scoliosis, and all of these patients had posterior rib tumors. Median overall survival for the entire cohort was 41.9±11.82months. Histology (p=0.003), location of tumor on the ribs (p=0.007), and surgical margins (p=0.011) were significantly associated with overall survival. Tumors on the middle and posterior (p=0.003) portions of the ribs had a lower chance of death. CONCLUSION: Scoliosis is more common in posterior rib resections. Histology, location of the tumor, and surgical margins impact survival, but, type of reconstruction does not. LEVEL OF EVIDENCE: III. TYPE OF STUDY: Treatment Study.
PURPOSE: Chest wall tumors in pediatric patients are rare. This study evaluates outcomes in pediatric patients who have undergone chest wall resections secondary to sarcomas. METHODS: A retrospective review was performed for patients <19years old who underwent chest wall resections for sarcoma 1999-2014 at the University of Texas MD Anderson Cancer Center. RESULTS: Of 44 patients, Ewing's sarcoma (n=18) and osteosarcoma (n=16) were most common. Other sarcomas included synovial sarcoma, chondrosarcoma, and rhabdomyosarcoma. Gore-Tex® or a Marlex™ mesh and methyl methacrylate sandwich was used in 22 patients, and 9 children did not require reconstruction. Twenty-four (54.5%) patients had normal activity, 3 (6.8%) had occasional discomfort, 2 (4.5%) had pain impairing function, 7 (15.9%) required medication or physical therapy for impairment, and 8 (18.2%) needed additional surgery. Five children (11.4%) developed scoliosis, and all of these patients had posterior rib tumors. Median overall survival for the entire cohort was 41.9±11.82months. Histology (p=0.003), location of tumor on the ribs (p=0.007), and surgical margins (p=0.011) were significantly associated with overall survival. Tumors on the middle and posterior (p=0.003) portions of the ribs had a lower chance of death. CONCLUSION:Scoliosis is more common in posterior rib resections. Histology, location of the tumor, and surgical margins impact survival, but, type of reconstruction does not. LEVEL OF EVIDENCE: III. TYPE OF STUDY: Treatment Study.
Authors: Simone de Campos Vieira Abib; Chan Hon Chui; Sharon Cox; Abdelhafeez H Abdelhafeez; Israel Fernandez-Pineda; Ahmed Elgendy; Jonathan Karpelowsky; Pablo Lobos; Marc Wijnen; Jörg Fuchs; Andrea Hayes; Justin T Gerstle Journal: Ecancermedicalscience Date: 2022-02-17
Authors: James A Saltsman; Enrico Danzer; William J Hammond; Daniel Rhee; Simon Berhe; Julie Monteagudo; Anita P Price; Todd E Heaton; David R Jones; Michael P LaQuaglia Journal: Ann Surg Date: 2021-08-01 Impact factor: 13.787
Authors: Courtney J Harris; Irene Helenowski; Andrew J Murphy; Sara A Mansfield; Michael P LaQuaglia; Todd E Heaton; Michele Cavalli; Joseph T Murphy; Erika Newman; Richard E Overmen; Tanvi T Kartal; Jo Cooke-Barber; Addison Donaher; Marcus M Malek; Ranjeet Kalsi; Eugene S Kim; Michael J Zobel; Catherine J Goodhue; Bindi J Naik-Mathuria; Imory N Jefferson; Jonathan P Roach; Claudia Mata; Nelson Piché; Shahrzad Joharifard; Serge Sultan; Scott S Short; Rebecka L Meyers; Josh Bleicher; Hau D Le; Kevin Janek; Andreana Bütter; Jacob Davidson; Jennifer H Aldrink; Holden W Richards; Elisabeth T Tracy; Sarah J Commander; Elizabeth A Fialkowski; Misty Troutt; Roshni Dasgupta; Timothy B Lautz Journal: Ann Surg Date: 2020-11-04 Impact factor: 12.969