Literature DB >> 27913976

Follistatin-like protein 1 suppressed pro-inflammatory cytokines expression during neuroinflammation induced by lipopolysaccharide.

Kai-Yuan Cheng1, Yi Liu1, Ying-Guang Han1, Jing-Kun Li1, Jia-Lin Jia1, Bin Chen1, Zhi-Xiao Yao1, Lin Nie1, Lei Cheng2.   

Abstract

Follistain-like protein 1 (FSTL1), has been recently demonstrated to be involved in the embryo development of nervous system and glioblastoma. However, the role of FSTL1 in neuroinflammation remains unexplored. In this study, the expression of FSTL1 in astrocytes was verified and its role was studied in neuroinflammation induced by in vivo intracerebroventricular (ICV) injection of lipopolysaccharide (LPS) or LPS treatment to astrocytes in vitro. FSTL1 was significantly induced after ICV LPS injection or LPS treatment. FSTL1 suppressed upregulation of pro-inflammatory cytokines in astrocytes after LPS treatment. Moreover, FSTL1 downregulated expression of pro-inflammatory cytokines through suppressing MAPK/p-ERK1/2 pathway in astrocytes. Our results suggest that FSTL1 may play an anti-inflammatory role in neuroinflammation mediated by astrocytes.

Entities:  

Keywords:  Anti-inflammatory; Astrocyte; FSTL1; Neuroinflammation

Mesh：

Substances：

Year:  2016        PMID： 27913976     DOI： 10.1007/s10735-016-9706-z

Source DB:  PubMed          Journal:  J Mol Histol        ISSN： 1567-2379            Impact factor:   2.611


  34 in total

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