Literature DB >> 27913952

Association of interleukin-18 and asthma.

Ming-Hui Xu1, Feng-Lai Yuan1, Shu-Jing Wang1, Hui-Ying Xu1, Cheng-Wan Li2, Xiao Tong3.   

Abstract

Cytokine-mediated immunity plays a dominant role in the pathogenesis of various immune diseases, including asthma. The recent identification of the family interleukin (IL)-1-related cytokine IL-18 now contributes to our understanding of the fine-tuning of cellular immunity. IL-18 can act as a cofactor for Th2 cell development and IgE production and also plays an important role in the differentiation of Th1 cells. Recent work identified an IL-18 association with the pathogenesis of asthma, wherein increased IL-18 expression was found in the serum of patients. Furthermore, IL-18 polymorphisms with susceptibility to asthma were reported, suggesting that IL-18 may be therapeutically relevant to asthma. In this review, we discuss the role of IL-18 in the pathogenesis of asthma and its therapeutic potential based on current research.

Entities:  

Keywords:  Asthma; IL-18; Th1 cell; Th2 cell

Mesh：

Substances：

Year:  2017        PMID： 27913952     DOI： 10.1007/s10753-016-0467-3

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  27 in total

Review 1.  Th1/Th2 cells.

Authors:  S Romagnani
Journal:  Inflamm Bowel Dis       Date:  1999-11       Impact factor: 5.325

Review 2.  IL-1 and IL-18 receptors, and their extended family.

Authors:  John E Sims
Journal:  Curr Opin Immunol       Date:  2002-02       Impact factor: 7.486

3.  Increased serum levels of soluble IL-18 receptor complex in patients with allergic asthma.

Authors:  Haruki Imaoka; Shin-ichi Takenaka; Tomotaka Kawayama; Hanako Oda; Yoichiro Kaku; Masanobu Matsuoka; Yuki Sakazaki; Paul M O'Byrne; Tomoaki Hoshino
Journal:  Allergol Int       Date:  2013-08-25       Impact factor: 5.836

4.  Chlamydia trachomatis mouse pneumonitis lung infection in IL-18 and IL-12 knockout mice: IL-12 is dominant over IL-18 for protective immunity.

Authors:  H Lu; X Yang; K Takeda; D Zhang; Y Fan; M Luo; C Shen; S Wang; S Akira; R C Brunham
Journal:  Mol Med       Date:  2000-07       Impact factor: 6.354

5.  Low interleukin (IL)-18 levels in sputum supernatants of patients with severe refractory asthma.

Authors:  Nikoletta Rovina; Efrossini Dima; Petros Bakakos; Eleni Tseliou; Konstantina Kontogianni; Spyros Papiris; Antonia Koutsoukou; Nikolaos G Koulouris; Stelios Loukides
Journal:  Respir Med       Date:  2015-03-19       Impact factor: 3.415

6.  The public health implications of asthma.

Authors:  Jean Bousquet; Philippe J Bousquet; Philippe Godard; Jean-Pierre Daures
Journal:  Bull World Health Organ       Date:  2005-07       Impact factor: 9.408

7.  [Serum interleukin 18 and 33 levels and its clinical significance in asthma patients].

Authors:  Dong-xia Yang; Na Li; Xiao-lin Zhang; Qi Wang
Journal:  Zhonghua Jie He He Hu Xi Za Zhi       Date:  2012-07

8.  Interleukin-18 and interleukin-18 receptor-α expression in allergic asthma.

Authors:  H Imaoka; G M Gauvreau; R M Watson; S G Smith; B Dua; A J Baatjes; K Howie; T Hoshino; K J Killian; H Aizawa; P M O'Byrne
Journal:  Eur Respir J       Date:  2011-10       Impact factor: 16.671

9.  Expression of the chemokine IP-10 correlates with the accumulation of hepatic IFN-gamma and IL-18 mRNA in chronic hepatitis C but not in hepatitis B.

Authors:  Sabine Mihm; Stefan Schweyer; Giuliano Ramadori
Journal:  J Med Virol       Date:  2003-08       Impact factor: 2.327

10.  Role played by Th2 type cytokines in IgE mediated allergy and asthma.

Authors:  Sudha S Deo; Kejal J Mistry; Amol M Kakade; Pramod V Niphadkar
Journal:  Lung India       Date:  2010-04
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  11 in total

1.  Assessment of Interleukin-8 in Bronchial Asthma in Iraq.

Authors:  M Faeqali Jan; H Muneer Al-Khafaji; B Hasan Al-Saadi; M K Aneed Al-Saedi
Journal:  Arch Razi Inst       Date:  2021-10-31

2.  Adenovirus vector-mediated YKL-40 shRNA attenuates eosinophil airway inflammation in a murine asthmatic model.

Authors:  Ling Wang; Aihua Bao; Ying Zheng; Aying Ma; Yi Wu; Huanxia Shang; Danruo Fang; Suqin Ben
Journal:  Gene Ther       Date:  2020-10-12       Impact factor: 5.250

3.  A comprehensive pathway map of IL-18-mediated signalling.

Authors:  D A B Rex; Nupur Agarwal; T S Keshava Prasad; Richard K Kandasamy; Yashwanth Subbannayya; Sneha M Pinto
Journal:  J Cell Commun Signal       Date:  2019-12-20       Impact factor: 5.782

4.  Emodin attenuated severe acute pancreatitis via the P2X ligand‑gated ion channel 7/NOD‑like receptor protein 3 signaling pathway.

Authors:  Qingkai Zhang; Xufeng Tao; Shilin Xia; Jialin Qu; Huiyi Song; Jianjun Liu; Hailong Li; Dong Shang
Journal:  Oncol Rep       Date:  2018-11-02       Impact factor: 3.906

Review 5.  Cell-Specific DNA Methylation Signatures in Asthma.

Authors:  Andrée-Anne Hudon Thibeault; Catherine Laprise
Journal:  Genes (Basel)       Date:  2019-11-15       Impact factor: 4.096

6.  Machine learning implicates the IL-18 signaling axis in severe asthma.

Authors:  Matthew J Camiolo; Xiuxia Zhou; Qi Wei; Humberto E Trejo Bittar; Naftali Kaminski; Anuradha Ray; Sally E Wenzel
Journal:  JCI Insight       Date:  2021-11-08

7.  Pet ownership in pregnancy and methylation pattern in cord blood.

Authors:  Hanna Danielewicz; Artur Gurgul; Anna Dębińska; Grzegorz Myszczyszyn; Tomasz Szmatoła; Anna Myszkal; Igor Jasielczuk; Anna Drabik-Chamerska; Lidia Hirnle; Andrzej Boznański
Journal:  Genes Immun       Date:  2021-10-12       Impact factor: 2.676

8.  18β-Glycyrrhetinic acid suppresses allergic airway inflammation through NF-κB and Nrf2/HO-1 signaling pathways in asthma mice.

Authors:  Jianming Liu; Yanqi Xu; Minyu Yan; Yingjie Yu; Yongmei Guo
Journal:  Sci Rep       Date:  2022-02-24       Impact factor: 4.379

9.  Relationship of Serum Levels of IL-17, IL-18, TNF-α, and Lung Function Parameters in Patients with COPD, Asthma-COPD Overlap, and Bronchial Asthma.

Authors:  Nailya Kubysheva; Marina Boldina; Tatyana Eliseeva; Svetlana Soodaeva; Igor Klimanov; Anastasia Khaletskaya; Venera Bayrasheva; Valery Solovyev; Luis Alfonso Villa-Vargas; Marco Antonio Ramírez-Salinas; Moisés Salinas-Rosales; Dmitry Yu Ovsyannikov; Ildar Batyrshin
Journal:  Mediators Inflamm       Date:  2020-07-12       Impact factor: 4.711

10.  Myrcene exerts anti-asthmatic activity in neonatal rats via modulating the matrix remodeling.

Authors:  Yanhui Du; Jie Luan; Ren Peng Jiang; Juan Liu; Yan Ma
Journal:  Int J Immunopathol Pharmacol       Date:  2020 Jan-Dec       Impact factor: 3.219
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